1H—MRS定量测定脑代谢物的研究  

Investigation of quantitative measurement of brain metabolite concentration using 1H nuclear magnetic resonance spectroscopy

作　　者：林艳[1] 饶海冰[1] 吴仁华[1] 

机构地区：[1]汕头大学医学院第二附属医院放射科,515041

出　　处：《国外医学（放射医学核医学分册）》2005年第2期85-88,共4页Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)

基　　金：国家自然科学基金资助项目(30270379/C010511)

摘　　要：磁共振频谱(magneticresonancespectroscopy,MRS)是利用核磁共振基本成像原理及其化学位移和自旋耦合现象,在活体上无创伤地测定能量代谢和体内化学物的一种检测技术,为疾病诊断和治疗提供有价值的信息。长期以来,MRS分析的脑代谢物检测结果以代谢物之间的比率来表达,但不可靠,近年来应用内标准和装有标准脑代谢物的外标准来获得脑代谢物的绝对浓度。在临床MRS应用中,代谢物绝对浓度的分析较比率分析有更多优点。本文就MRS的基本原理及1H鄄MRS定量测定脑代谢物浓度的方法作一综述。Magnetic resonance spectroscopy based on the principles of magnetic resonance, the chemi-cal shift, and spin coupling is a technique that allows examination of the metabolites and biochemical nature in vivo without the need for invasive procedures. Non-invasive detection of metabolite concentration using MR spectroscopy can provide valuable information in diagnosis and treatment of diseases. In localized brain MR spectroscopy, the measurement results of brain metabolites had often been expressed as ratios rather than as absolute concentration; however, drawbacks of ratios have been mentioned in the literature. More recently MR spectroscopists have paid attention to acquire absolute concentrations using internal reference or external reference filled with brain metabolites. Concerning metabolite analysis in clinical MR spectroscopy studies, absolute concentrations have advantages over metabolite ratios. This article reviewed the principle of MRS and its methods in quantitative measurement of brain metabolite concentrations.

关 键 词：磁共振氢频谱 比率 内标准 外标准 脑代谢物 

分 类 号：R445.2[医药卫生—影像医学与核医学]