天麻钩藤方对肾性高血压大鼠左室及主动脉肥厚干预作用的研究  

Effect of Tianma Gouteng recipe on interfering LV and aortic hypertrophy in renovascular hypertension rats

作　　者：王丹巧[1] 王巍[1] 孙晓芳[1] 赵德忠[1] 杜贵友[2] 

机构地区：[1]中国中医研究院西苑医院,北京100091 [2]中国中医研究院中药研究所,北京100700

出　　处：《中国中药杂志》2005年第8期606-609,共4页China Journal of Chinese Materia Medica

基　　金：国家中医药管理局资助项目 (国中医药科2 0 0 2LHR0 6;2 0 0 3 2 0 0 5 )

摘　　要：目的:探讨天麻钩藤方对肾性高血压大鼠左室、主动脉肥厚的干预作用及对组织血管紧张素Ⅱ(AngⅡ)的影响。方法:用肾动脉狭窄高血压大鼠模型,随机分为模型组、依那普利组、天麻钩藤方组。连续投药6周,每2周测血压1次。处死动物后,称量左室及主动脉湿重,观察心脏、主动脉病理学变化,测定心脏、主动脉组织AngⅡ水平。结果:模型组大鼠术后1周,收缩期血压平均上升37 4mmHg ,7周后,出现明显的左室肥大和主动脉肥厚的病理改变,心脏和主动脉组织的AngⅡ升高(P均<0. 0 1) ;与模型组相比,依那普利治疗,降低了血压、改善了组织病理学的变化(P <0 . 0 5或P <0. 0 1) ;天麻钩藤方治疗,改善了左室和主动脉的湿重及其病理学变化,抑制了心脏和主动脉组织的AngⅡ升高(P <0. 0 5或P <0 . 0 1)。结论:天麻钩藤方逆转了肾性高血压大鼠心肌和主动脉肥厚的病理改变,降低了心脏、主动脉组织AngⅡ的升高。Objective: To investigate the effect of Tianma Gouteng recipe(TGR) on interfering left ventricular(LV)and aortic hypertrophy and tissue angiotensinⅡ(Ang Ⅱ) in rats with renovascular hypertension . Method: The animal model of renovascular hypertension was used in this experiment. Hypertensive rats were randomly allocated into model group, Enalapril group and TGR group, and the drugs were used for 6 weeks continuously. During this period, the blood pressure of rats was measured every two weeks. After rats were sacrificed, the wet weight, tissue Ang Ⅱ level of LV and aorta, and the cardiac index were measured. Result:One week after renovascular stenosis, the systolic blood pressure(SPS)of model group was increased by 37.4 mmHg, and 7 weeks after stenosis, the LV and aortic hypertrophy was obvious increased, meanwhile,tissue Ang Ⅱof LV and aorta was raised markedly (P<0.01). Contrasting with the model group, blood pressure was reduced and the morphological index was improved in Enalapril group respectively (P<0.05 or P<0.01); the wet weight of LV and aorta were reduced, the morphological index was improved, the rise of Ang Ⅱin tissue was suppressed, in TGR group significantly. Conclusion: TGR can attenuate myocardial and aorta hypertrophy induced by renovascular hypertension, and suppress the rise of Ang Ⅱin tissue significantly. This suggests that TGR has the effects on interfering LV and aortic hypertrophy by an independent-antihypertensive way.

关 键 词：肾性高血压大鼠 主动脉肥厚 天麻钩藤 干预作用 主动脉组织 组织血管紧张素Ⅱ 高血压大鼠模型 病理学变化 依那普利 病理改变 0.05 肾动脉狭窄 收缩期血压 组织病理学 Ang 左室肥大 大鼠心肌 心脏 测血压 升高 湿重 治疗 

分 类 号：R285.5[医药卫生—中药学] R972.4[医药卫生—中医学]