性激素对系统性红斑狼疮患者免疫功能的影响　一、女性SLE患者血清雌二醇、睾酮与其细胞免疫功能相关性研究  

Relative Research of Serum Estradiol, Testosterone Level and Cellular Immune Function in Female Patients with Systemic Lupus Erythematosus

作　　者：杜乾君[1] 熊声忠[1] 高庆林[1] 张宇[1] 郭实士[1] 

机构地区：[1]湖南医科大学附属湘雅医院皮肤科,湖南医科大学免疫研究室

出　　处：《中国皮肤性病学杂志》1994年第3期145-146,共2页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金

摘　　要：本文测定了５０例女性ＳＬＥ患者血清雌二醇、睾酮水平，其中３２例检测了其ＰＢＭＣ产生ＩＬ－２活性，２３例检测了其ＰＢＭＣ产生γ－干扰素活性。结果表明：患者血清雌二醇升高，睾酮下降（Ｐ＜０．０１），其ＰＢＭＣ产生ＩＬ－２活性降低，且初发患者血清雌二醇水平与其ＰＢＭＣ产生ＩＬ－２活性呈直线负相关。为进一步阐明ＳＬＥ发病机理提供了线索。The serum concentration of estradiol(E2), testosterone(Te) were determined in 50 female patients with systemic lupus erythematosus(SLE),and interleukin-2(IL-2) activity produced by peripheral blood mononuclear cells(PBMC) of 32 patients, and interferon-γ(IFNγ) activity produced by PBMC of 23 patients were determined in these 50 female patients with SLE.The results indicated that (1) the E2 concentration was significantly increased (P<0. 01),and the Te concentration was significantly decreased in serum(P<0.01). (2) IL-2 activities were decreased markedly compared with that of controls(P<0. 05), no difference was found in activities of IFNγ between SLE patients and controls (P>0. 05). (3) there was a linear negative correlation between the serum E2 concentration with the activities of IL-2 in new patients (γ=-0. 606,P<0. 01 ). This may be helpful for understanding the etiopathology of SLE.

关 键 词：红斑狼疮 雌二醇 睾酮 免疫功能 

分 类 号：R593.241[医药卫生—内科学]