高血压鼠局部脑梗塞后微血管改变的动态观察  

The sequential observation of microvascular changes in renovascular hypertensive rats after occlusion of the middle cerebral artery

作　　者：方燕南[1] 黄如训[1] 陈燕奎[1] 苏镇培[1] 陈颖贤[1] 

机构地区：[1]中山医科大学附一院神经科

出　　处：《中国神经精神疾病杂志》1994年第4期201-203,200,共4页Chinese Journal of Nervous and Mental Diseases

基　　金："八.五"国家医学科学科技攻关项目

摘　　要：本文用透视电镜动态观察肾血管性高血压鼠（ＲＨＲ）和正常鼠（ＳＤＲ）在单侧大脑中动脉闭塞（ＭＣＡｏ）后２小时至７天的梗塞灶边缘区脑微血管的超微结构改变。显示局部脑缺血后微血管的严重损害以ＭＣＡｏ后３天为高峰期，以ＲＨＲ更严重，说明持续性高血压在其中起着重要的作用。结果表明微血管本身结构的改变是导致管腔狭窄的内因，微血管结构的水肿改变在管腔闭塞中具有决定性作用，而ＲＨＲ的内皮损害和微血栓形成也是重要的，故高血压对脑梗塞的影响是不容忽视的，提示临床调整血压有其积极意义。In the present study, we sequentially observed the ultrastructural changes of cerebral ndcrovessel in different period (2 hours to 7 days ) following occlusion of the middle cerebral artery (MCAo) in renovascular hypertensive rats (RHR) and healthy sparque-dawley rats (SDR) by electron microscope.Our data indicate that the damage of microvascular structure became the most serious on the third day after MCAo. The microvascular damage in the bor der of infarct focus in RHR was more severe than in SDR. It is suggested that chronic hypertension may play an important part in the microvascular damage. We consider the damage of microvascular structure itself may be internal cause of microva scular compression, The microvascular edema could play a decisive role in microvascular compression. The endothelial damage and microvascular throm bosis were important too. The effects of hyperten tion on stroke, therefore, can not be neglected. It is necessary to regulate blood pressure clinically.

关 键 词：高血压 脑梗塞 微血管 超微结构 

分 类 号：R544.106[医药卫生—心血管疾病]