甲氨蝶呤缓释植入剂体外释放方法的研究  

Studies on the in vitro release method of the sustained-release implant of methotrexate

作　　者：储成顶[1] 郭智勇[1] 刘飞[2] 俞敏[2] 鲍玉婷[2] 马晓芹[2] 

机构地区：[1]安徽医科大学理化中心,合肥230032 [2]合肥工业大学控释药物研究所,合肥230009

出　　处：《中国新药杂志》2005年第4期438-440,共3页Chinese Journal of New Drugs

基　　金：中华人民共和国科学技术部基础研究快速反应支持项目(国科基字[2001]51号);安徽省教育厅高教实验研究2002专项基金

摘　　要：目的:建立甲氨蝶呤缓释植入剂体外释放方法。方法:选择影响甲氨蝶呤缓释植入剂体外释放的重要影响因素进行正交试验,优选释放条件。结果:最优参数如下:介质为偏碱性等渗液,介质浓度为25%,介质体积为200mL,搅拌转速为50r·min^(-1)。结论:所定方法可用于甲氨蝶呤植入剂的体外释放测试。Objective:To establish the in vitro release method of the sustained-release implant of methotrexate. Methods: The release conditions were optimized based on the orthogonal design that included factors affecting the sustained release in vitro of the methotrexate implant. Results:The optimal characteristics were as follows: basic isosmotic solution with the concentration at 25%,the volume at 200mL and the rotate speed at 50r·min^(-1). Conclusion: The dissolution method may be used to assess the drug delivery in vitro of methotrexate implants.

关 键 词：甲氨蝶呤 缓释植入剂 体外释放 正交试验 

分 类 号：R979.12[医药卫生—药品] R944.9[医药卫生—药学]