碱性成纤维细胞生长因子对难治性突发性聋的疗效评价  

The efficacy of bFGF therapy for refractory sudden deafness

作　　者：魏佑震 洪岸[2] 张磊[3] 毕景云[4] 王茂才[4] 康颂建[5] 史献君[5] 

机构地区：[1]广州开奇医药生物技术有限公司,广州510620 [2]暨南大学生物工程研究所,广州510632 [3]泰安市第一人民医院耳鼻咽喉科,泰安271000 [4]泰安市中心医院耳鼻咽喉科,泰安271000 [5]泰山医学院听觉生理研究室,泰安271000

出　　处：《中国新药杂志》2005年第4期467-469,共3页Chinese Journal of New Drugs

基　　金：广州市科技局资助课题(Z18-03-29)

摘　　要：目的:探讨碱性成纤维细胞生长因子(bFGF)对难治性突发性聋的疗效。方法:将208例(266耳)接受正规疗程治疗后,疗效不显著或不满意而有意继续接受治疗,病程在4个月内的突发性聋患者,按照就诊先后顺序分成治疗组104例(135耳)和对照组104例(131耳)。治疗组肌注bFGF4000u,qd,连用15～30d;对照组用维生素B_1100mg加维生素B_(12)500μg混合肌注,或B族维生素口服,qd,连用15d。治疗前后均行纯音电测听及脑干听觉诱发电位。结果:治疗前听阈治疗组为(58.36±27.58)dB pe SPL,对照组为(59.82±28.45)dB pe SPL(P>0.05);治疗后治疗组听阈为(41.89±23.45)dB pe SPL,对照组为(56.73±33.15)dB pe SPL(P<0.01)。有效率治疗组为97%,对照组为38.9%,差异有显著性(P<0.01)。结论:bFGF治疗突发性聋有较大的治疗时间窗,疗效可靠、显著。Objective: To assess the efficacy of basic fibroblast growth factor(bFGF) therapy for refractory suddenly sensorineural hearing loss. Methods:The study is an open label study that evaluated 208 patients (266 ears) with refractory sudden deafness that have suffered from such hearing loss only for 4 months or less and failed prior standard therapy. The patients were assigned to receive daily either 4 000 U bFGF (i.m.,n=104,135ears) for 15～30 days or combination of vitamin B_1(100mg) with B_(12)(500mg) (i.m.) or multiply vitamin B (p.o.) (n=104,131 ears) for 15 days based on the enrollment order. Prior to and post the therapy, the brainstem auditory evoked potential (BAEP) and pure tone audiometry were compared. Results: The auditory threshold prior to and post the therapy in the bFGF-treated patients was (58. 36±27. 58) versus (41. 89±23. 45) dB pe SPL, compared with (59.82+28.45) versus (56. 73±33. 15)dB pe SPL in the vitamin B-treated patients. The bFGF groups showed a significant difference from the vitamin groups in the auditory threshold post therapy (u=4. 204, P<0. 01). In addition, a significant difference was found in the recovery rate between the bFGF-treated patients and the vitamin B-treated patients (55.6% vs. 6.9%) and in the overall response rate (97% vs. 38.9%) (P<0.01). Conclusion: bFGF is a potential option in the treatment of the sudden sensorineural hearing loss.

关 键 词：碱性成纤维细胞生长因子 突发性聋 脑干听觉诱发电位 

分 类 号：R764.43[医药卫生—耳鼻咽喉科] R969.4[医药卫生—临床医学]