三种方法检测流行性出血热病毒自然感染和疫苗免疫后的抗体水平比较  

Comparison of Detecting Antibodies in Persons Naturally Infected with EHF Virus or Immunized with EHF Vaccine by Three Methods

作　　者：姚智慧[1] 俞永新[1] 杨立宏[1] 

机构地区：[1]中国药品生物制品检定所

出　　处：《中国人兽共患病杂志》1994年第1期9-10,共2页Chinese Journal of Zoonoses

摘　　要：应用高密度颗粒凝集试验（ＨＤＰＡ）、反向血凝抑制试验（ＲＰＨＩ）和空斑减少中和试验（ＰＲＮＴ）三种方法对我国出血热疫苗人体免疫后和出血热病毒自然感染人体后的抗体水平进行检测比较，结果三种方法检出阳性率基本一致，但ＨＤＰＡ、ＲＰＨＩ的抗体水平较ＰＲＮＴ为高。不显性感染者的抗体水平较显性感染者低。自然感染者的中和抗体水平较疫苗免疫者高。We have studied a comparison for detecting antibodies in naturally infected and vaccine immunized persons by High density particle agglutination(HDPA) Reversed passive hemagglutination inhibition(RPHI) and Plaque reduction neutralization tests(PRNT).The results showed that the pasitive rates by the three methods were similar detected,but the antibody titers tests by HDPA and RPHI were higher than that by PRNT. The results also showed that of patients,and the neutralizing antibodies tested by PRNT were higher in naturally infected persons than in vaccinees.

关 键 词：流行性出血热 颗粒凝集试验 抗体 

分 类 号：R392.11[医药卫生—免疫学]