心力衰竭患者脑钠素水平与左室内径的相关性探讨  

Relationship Between Concentration of Brain Natriuretic Peptide and Left Ventricular end Diastolic Diameter in Patients with Heart Failure

作　　者：何军[1] 王旭辉[2] 刘晓方[1] 

机构地区：[1]宁夏医学院附属医院心内科,银川750004 [2]解放军第五医院特诊科,银川750004

出　　处：《宁夏医学院学报》2005年第2期113-114,118,共3页Journal of Ningxia Medical College

摘　　要：目的探讨心力衰竭患者血浆脑钠素水平与左室舒张末内径的关系。方法将62例心力衰竭患者分为A、B、C三组,24例健康人做为对照组,用床旁快速放射免疫法测定所有入选对象的血浆脑钠素水平,经超声心动图测定心脏左室舒张末内径和射血分数。结果心力衰竭患者血浆脑钠素水平显著升高,且与左室舒张末内径呈正相关,r=0.236,P=0.032;与射血分数呈负相关,r=-0.331,P=0.004。结论心力衰竭患者血浆脑钠素水平随着左室内径扩大而升高,并与心衰严重程度密切相关。Objective To assess the relationship between the concentration of brain natriuretic peptide (BNP) and left ventricular end diastolic diameter(LVEDD) in patients with heart failure(HF). Methods Sixty-two patients with HF were divided into three groups. Twenty-four healthy persons enrolled as the control group. The concentrations of BNP in all subjects were measured by Biosite Diagnostics. The LVEDD and ejection fraction(EF) were measured by echocardiography. All data were analyzed by SPSS 10.0. Results The plasma level of BNP increased significantly in patients with HF. The elevation of BNP was correlated to LVEDD positively(r=0.236, P=0.032), but correlated to EF negatively(r=- 0.331, P=0.004).Conclusion The plasma level of BNP increased along with the enlargement of LVEDD in HF. This elevation was highly related to the severity of heart failure.

关 键 词：心力衰竭患者 左室内径 相关性探讨 水平 血浆脑钠素 放射免疫法测定 左室舒张 射血分数 超声心动图 严重程度 对照组 健康人 正相关 负相关 升高 

分 类 号：R541.6[医药卫生—心血管疾病]