阿奇霉素注射液与注射用乳糖酸红霉素多中心随机对照治疗急性细菌性感染临床评价  

A multi-center controlled clinical trial of azithromycin injection and erythromycin injection in the treatment of acute bacterial infection

作　　者：崔洪[1] 李家泰[1] 侯芳[1] 吕媛[1] 薛峰[1] 杨武 孙永华[3] 阎汝蕴[3] 吴雅伦[4] 韩晓文[4] 霍颖芳[4] 王增贵[4] 石玉珍[5] 蒋俊康[5] 杨红申[5] 

机构地区：[1]北京大学第一医院临床药理研究所,北京100034 [2]山西亚宝药业集团股份有限公司,太原044600 [3]北京积水潭医院,北京100035 [4]河北省人民医院,石家庄050000 [5]河北医科大学第二医院,石家庄050000

出　　处：《中国抗生素杂志》2005年第5期284-288,共5页Chinese Journal of Antibiotics

摘　　要：目的评价阿奇霉素注射液治疗急性呼吸道感染、泌尿道感染及皮肤软组织感染的安全性和有效性。方法阿奇霉素注射液静脉滴注,每次250mg,每日1次,首次剂量加倍,疗程5d;对照药红霉素每日1g^1.5g,分1~2次静脉滴注,疗程7~14d。结果阿奇霉素注射液与红霉素随机对照治疗呼吸道、泌尿道及皮肤软组织感染134例,其中试验组69例,对照组65例。试验组与对照组的临床有效率(停药后1周)分别为94.2%与75.5%,细菌清除率分别91.9%与83.3%;不良反应发生率分别为8.45%与24.62%,以上结果经统计学处理有显著性差异(P<0.05)。结论阿奇霉素注射液静脉点滴,每次250mg,每日1次,首次剂量加倍,对敏感致病菌引起的轻、中度呼吸道感染,泌尿道感染及皮肤软组织感染均有很好临床疗效和细菌学疗效,不良反应发生率低。Objective To compare the clinical efficacy and safety of azithromycin injection and erythro-mycin injection in the treatment of moderate to severe bacterial infections. Methods A randomized controlled multi-center clinical trial was conducted for the treatment of hospitalized patients with respiratory tract infection, urinary tract infections and soft tissue infections. The dosage of azithromycin was intravanous infusion for 0.25g, once daily for 5 days and erythromycin 1～1.5g once or twice a day for 7～14 days. Results Results showed that the efficacy rates were 94.2% and 78.5%; the bacterial clearance rate were 91.9% and 83.3%; the incidence of adverse reaction were 8.45% and 24.62%, respectively. It showed that there was statistical difference between the two groups (P<0.05). Conclusion Azithromycin injection is a safe and effective drug in the treatment of respiratory tract infection, urinary tract infections and soft tissue infections.

关 键 词：阿奇霉素注射液 红霉素注射液 细菌性感染 

分 类 号：R969[医药卫生—药理学]