牛磺酸对心血管系统作用及机理的研究进展  

Progress in research on function and mechanism of cardiac vascular system of taurine

作　　者：华浩明[1] 伊藤崇志[2] 邱志刚[2] 东纯一[2] 

机构地区：[1]南京中医药大学基础医学院,江苏南京210029 [2]大阪大学大学院薬学研究科,日本大阪5650871

出　　处：《中国中药杂志》2005年第9期653-658,共6页China Journal of Chinese Materia Medica

基　　金：国家留学基金委国家留学基金项目(22832037)

摘　　要：牛磺酸对心血管系统作用广泛,机制复杂,主要有抑制心肌细胞凋亡,保护因缺血等所致心肌损伤;恢复因高糖、胆固醇、吸烟和同型半胱氨酸所致血管内皮功能异常;抑制血管平滑肌细胞增殖,减少血管平滑肌钙化;促进高脂血症动物模型的胆固醇代谢和排泄而降脂;经对髓过氧化酶、牛磺酸氯胺和核因子κB等抗氧化而抑制动脉硬化;牛磺酸的作用需依赖其跨细胞膜转运功能,但病态心肌和血管细胞牛磺酸转运异常;此外,对果糖所致高血压和铁超载所致心血管系统损害的动物模型均有改善作用等。The function for cardiac vascular system of taurine is extensive, and the mechanism is complicated. Taurine protects the cells from the cell injury caused by ischemia etc. Through repressing apoptosis,prevents endothelial dysfunction caused by hyperglycemia, hypercholesterolemia, smoking and homocysteine; suppresses the proliferation and calcification in vascular smooth muscle cells, promotes metabolization and excretion of cholesterol in the animal models of hyperlipemia, and confers the resistance to an oxidant, hypochlorous acid, produced by neutrophil on cells, and taurine chrolamine to inhibit activation of NF-kappaB, which might be associated with anti-atherosclerotic effect. Taurine mainly acts inside the cell. Howeres, taurine transport system becomes aberrant in pathological myocardial and vascular tissue. In addition, taurine improves cardiovascular function in fructose-induced hypertension and an iron-overload murine animal models.

关 键 词：心血管系统作用 血管平滑肌细胞增殖 血管内皮功能异常 心血管系统损害 机理 心肌细胞凋亡 同型半胱氨酸 核因子-κB 动物模型 胆固醇代谢 髓过氧化酶 牛磺酸转运 心肌损伤 高脂血症 动脉硬化 转运功能 血管细胞 改善作用 

分 类 号：R285[医药卫生—中药学]