同种异体羊肱骨片移植的生物力学参数实验研究  

BIOMECHANICAL STUDIES ON BONE ALLOGRAFTS IN SHEEP HUMERUS

作　　者：杜守继[1] 张宏民[1] 杨育勇[1] 吴文周[1] 雷刚[1] 孟宪钰[1] 石占成[1] 刘赫臣 

机构地区：[1]太原工业大学,中国辐射防护研究院

出　　处：《中国生物医学工程学报》1994年第2期118-123,共6页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金;山西省自然科学基金

摘　　要：本文在同种异体辐照灭菌ＡＡＡ骨片植入羊肱骨的实验基础上，应用单轴拉伸试验，测试分析了不同周期（植入时间为３，６，９，１２个月）植骨和正常对照侧骨的生物力学参数（弹性模量Ｅｍ、极限强度σｕ、极限应变εｕ等）。结果表明，ＡＡＡ骨植入的最初三个月，植骨的力学参数（Ｅｍ、σｕ、εｕ等）有较大幅度的下降，其弹性模量Ｅｍ仅达到正常骨的１０．２％，极限强度σｕ达到正常骨的３．５％。随着植入时间的增长，Ｅｍ、σｕ、εｕ逐渐增加，并向正常值靠拢。ＡＡＡ骨植入１２个月后，植骨弹性模量Ｅｍ达到正常骨的６０％，极限强度σｕ达到正常骨的５０％，极限应变εｕ达到正常骨的６３．８％。根据前四个周期（移植１２个月）植骨力学参数的增长幅度，预计植骨力学参数恢复到正常水平的移植周期：弹性模量Ｅｍ约３０个月、极限强度σｕ约２２个月、极限应变εｕ约１５个月左右。Biomechanical parameters,( Em, σu, εu)of AAA (Antig enextracted Auto digested Allograft) bone implant in sheep humerus were studied 3,6,9 and 12 months postoperatively by axial tension test and compared with normal control cortical bone. 3 months after AAA bone implant, there was significant decrease in biomechanicai parameters of bone implant. The Yong's moduli (Em) and utimate strength (σu) were only 10.2% and 3.5% of use of normal control cortical bone. The biomechanical parameters(Em,σu,εu)of bone implant increased with the prolongation of post implantation days. By the end of 12 months, the values of Em, σu and ultimate strain εu of the implant reached 60, 50 and 63.8% of those of normal contol bone respectively. According to the increasing rate of biomechanical parameters of bone implant during the first 12 month, it was estimated that the time needed for the complete recovery of biomechanical parameters (Em, σu,εu )of the implant was 30, 20 and 15 months respectively.

关 键 词：生物力学 参数 AAA骨植片 肱骨 

分 类 号：R318.01[医药卫生—生物医学工程]