不同温度保存的冻干卡介苗接种后的免疫效果  

Immunologic Efficacy of Freeze-dried BCG Vaccine Stored at Different Temperatures

作　　者：杜广洲[1] 王红艳[1] 张学志[1] 张碧波[1] 夏德金 陈伟 杨淑云 李淑艳 

机构地区：[1]黑龙江省结核病防治所,呼兰150500 [2]鹤岗矿务局结核病防治所

出　　处：《中国生物制品学杂志》1994年第4期181-182,共2页Chinese Journal of Biologicals

摘　　要：分别在－20℃、2～8℃和11～20℃，保存3个月的冻干皮内卡介苗活菌残存数分别为6．70×106／mg、1．26×107／mg、7．3×106／mg，接种492名新生儿，阳转率分别为83．56％、83．44％和82．46％，硬结平均直径分别为5．8、6．70和6．02mm，卡痕平均直径分别为4．68、4．11和4．27mm，表明冻干皮内卡介苗在－20℃冰柜中和11～20℃常温下保存3个月仍可使用。The residual viable counts of freeze-dried BCG vaccine stored at -2℃, 2~8℃ and 11~20℃ for 3 months were 6.70×106, 1. 26×107 and 7. 30×106/mg, respectively.192 infants were vaccinated with the vaccine stored at the 3 temperatures, and the result showed that the conversion rates were 83. 66%, 83. 44% and 82. 46%, respectively; and scleroma average diameters were 5. 8, 6. 07 and 6. 02mm, respectively; scar average diameters were 4. 68, 4. 11 and 4. 27mm, respectively. It proved that freeze-dried BCG vaccine still could be used after being stored at -20℃ or 11~20℃ for 3 months.

关 键 词：阳转率 结核菌苗 免疫效果 

分 类 号：R392－33[医药卫生—免疫学] R186.2[医药卫生—基础医学]