褪黑素受体在Graves病患者外周血白细胞上的表达  

Expressions of melatonin receptors on peripheral blood leukocytes in patients with Graves disease

作　　者：杨建明[1] 邹秀兰[1] 许青 刘志民[3] 

机构地区：[1]湖北省宜昌市第一人民医院内分泌科,443000 [2]上海市长宁区西效绿地医院 [3]上海市长征医院内分泌科

出　　处：《医师进修杂志》2005年第5期34-35,38,共3页Journal of Postgraduates of Medicine

摘　　要：目的　探讨Graves病(GD)患者外周血白细胞褪黑素受体(MR)结合容量的变化及其意义。方法　随机选择GD患者39例,正常对照组39例,以1 2 5I-褪黑素(MT)为配体,应用放射配体法测定1 2 :0 0时(光中期)外周血白细胞1 2 5I-褪黑素特异结合部位(MR)的结合容量,比较两组之间的差异。结果　一点法分析显示,GD患者组光中期MR结合容量明显低于对照组,分别为(0 .2 0 2±0 .0 6 4 )fmol 1 0 6 细胞和(0 .381±0 .0 5 6 )fmol 1 0 6 细胞,t=1 3.0 97,P <0 .0 1 ,两组差异非常显著。结论　GD患者外周血白细胞MR结合容量的降低,影响了MT对下丘脑-垂体-甲状腺轴的抑制以及对免疫系统的调节作用,可能有助于GD的发生。ObjectiveTo examine the alteration of the level of melatonin receptors (MR) of the peripheral blood leukocytes in the patients with Graves disease (GD). Methods Radioligand assay was used to measure the MR binding capacity of the peripheral blood leukocytes in 39 patients with GD and 39 healthy controls at 12:00. Results Patients with GD were found to have lower MR than healthy controls,(0.202± 0.064) fmol/106 cells vs (0.381±0.056) fmol/106 cells,respectively;t=13.097,P<0.01. Conclusion These findings demonstrated that patients with GD had decreased level of MR and implied the decrease of MR in patients with GD had the inhibitory effect of MT on hypothalamic-pituitary-thyroid axis,which may be involved in mechanism of GD.

关 键 词：外周血白细胞 褪黑素受体 GRAVES病 患者 下丘脑-垂体-甲状腺轴 结合容量 正常对照组 放射配体法 结合部位 调节作用 免疫系统 GD 其意义 一点法 中期 MR 

分 类 号：R541.4[医药卫生—心血管疾病] R335.9[医药卫生—内科学]