不同复方丹参片(滴丸)紫外吸收光谱的相关分析  

A correlate analysis of UV absorption spectra of compound Danshen tablets from different manufactures

作　　者：莫志江[1] 张丽娟 

机构地区：[1]广西壮族自治区人民医院,广西南宁530021 [2]内蒙古自治区满州里铁路医院,内蒙古满洲里021400

出　　处：《中国中药杂志》2005年第7期507-510,共4页China Journal of Chinese Materia Medica

摘　　要：目的:评估UV吸收光谱在复方丹参片(滴丸)的鉴别和质量控制中的价值。方法:利用紫外分光光度计扫描不同厂家的复方丹参片、滴丸,以及其他不同品种中成药的UV吸收光谱(以水为溶剂)。对药物的UV吸收光谱进行相关分析,得到各产品之间的相互关系表,并依据表中的Pearson相关系数(R)和ΔR(PearsonsR与它的镜像位置值的绝对差值)对光谱的相似性进行比较。结果:相同厂家不同批号产品之间的UV吸收光谱的R=0.997～0.9999,光谱相似性极高;而不同厂家产品之间的R=0.92～0.997,ΔR<0.02,光谱相似性较高;与复方丹参片(滴丸)的UV吸收光谱相比,其他中成药光谱的R=0.25～0.98,ΔR>0.02,光谱相似性低。结论:UV吸收光谱可以用于复方丹参片(滴丸)的鉴别和质量控制。Objective: To evaluate the value of UV absorption spectrum for identification and quality control of compound Danshen tablets and pills. Method: UV absorption spectra of compound Danshen tablets and pills, and other drugs were scanned using ultraviolet spectrophotometer(water as the solvent). Pearsons correlation coefficients(Pearsons R ) were displayed in the correlations table obtained from SPSS correlate, and ΔR defined as the absolute value of the difference between Pearsons R and its mirror image in the table were used for measuring the spectral similarity between two drugs from different manufacturers. Result: Regarding compound Danshen tablets and pills, the spectral similarity between different batch drugs from same manufacturer was very high with Pearsons R =0.995-0.999 9, and the similarity between two manufacturers was high with Pearsons R =0.92-0.997 and ΔR <0.02. Compared with the spectra of compound Danshen tablets and pills, the spectral similarity of the other drugs was low with Pearsons R =0.25-0.98 and ΔR >0.02. Conclusion: The results showed that UV absorption spectrum could be suitable for identification and quality control of compound Danshen tablets and pills.

关 键 词：复方丹参片 相关分析 紫外吸收光谱 滴丸 紫外分光光度计 Pearson 质量控制 不同厂家 相似性 相互关系 相关系数 不同批号 中成药 UV 同品种 产品 鉴别 

分 类 号：R286.0[医药卫生—中药学]