葛根素对大鼠急性脑缺血损伤Hsp70表达的影响  

Effect of puerarin on the expression of Hsp70 in the rats with cerebral injury induced by acute local ischemia

作　　者：潘洪平[1] 莫祥兰[1] 杨嘉珍[1] 李吕力[1] 黄振录[1] 叶劲[1] 黄进[1] 

机构地区：[1]广西壮族自治区人民医院,广西南宁530021

出　　处：《中国中药杂志》2005年第7期538-540,共3页China Journal of Chinese Materia Medica

基　　金：广西壮族自治区卫生厅医药卫生科研课题(Z2001072)

摘　　要：目的:探讨葛根素对大鼠急性脑缺血损伤Hsp70表达的影响。方法:采用闭夹大脑中动脉造成局部脑缺血模型,对脑组织用免疫组化SP法作Hsp70染色,观察其Hsp70表达情况。结果:葛根素干预组Hsp70表达强度显著强于单纯缺血组(P<001)。结论:葛根素有上调大鼠急性脑缺血损伤时Hsp70表达的作用。Objective: To study the effect of puerarin on the expression of Hsp(heat shock protein)70 in the rats with cerebral injury induced by acute local ischemia. Method: Rat model of acute local cerebral ischemia was made by ligating middle cerebral artery. The Hsp70 expression in brain tissue was detected by SP method of immunohistochemistry. Result: The expression of Hsp70 was significantly higher in puerarintreated rats than those in the rats with cerebral ischemia. Conclusion: Puerarin can enhance the level of Hsp70 expression in the rats with cerebral injury induced by acute local ischemia.

关 键 词：HSP70表达 急性脑缺血损伤 葛根素 大鼠 局部脑缺血模型 免疫组化SP法 大脑中动脉 表达情况 脑组织 

分 类 号：R285.5[医药卫生—中药学]