复方葛根素对脑缺血损伤保护的实验研究  

Experimental study of protective effect of pueraria compound on the cerebral ischemic injury

作　　者：赵雍[1] 杜贵友[1] 崔海峰[1] 曹春雨[1] 王秀荣[1] 张春颖[1] 

机构地区：[1]中国中医研究院中药研究所,北京100700

出　　处：《中国中药杂志》2005年第7期548-551,共4页China Journal of Chinese Materia Medica

摘　　要：目的:探讨复方葛根素对脑缺血再灌注损伤的保护作用。方法:采用大鼠大脑中动脉栓塞模型、沙土鼠全脑缺血再灌模型和小鼠脑缺血再灌3种动物模型,研究复方葛根素对脑缺血再灌注脑含水量和梗塞范围、脑卒中指数和脑组织中乳酸(LA)、乳酸脱氢酶(LDH)、过氧化脂质(LPO)、谷胱甘肽过氧化物酶(GPX)、Na+K+ATP酶的影响。结果:复方葛根素能明显降低大脑中动脉大鼠脑含水量,缩小脑梗死面积,改善全脑缺血再灌注沙土鼠运动能力,降低缺血再灌小鼠LA和LPO的含量,提高LDH,GPx和Na+K+ATP酶的活性。结论:复方葛根素具有抗氧化和保护缺血脑组织的作用。Objective: To discuss the protective effects of pueraria compound on the cerebral ischemic injury. Method: Using the middle cerebral artery occlusion model(MCAO)in rats and cerebral ischemia-reperfusion models in gerbils and mice, we investigated the influence of pueraria compound on the brain water content and the infarct size, the cerebral apoplexy exponent, the contents of lactic acid(LA)and lipid peroxide(LPO), the activities of lactic dehydrogenase(LDH), glutathione peroxidase(GP X )and Na + -K + -ATPase. Result: Pueraria compound obviously reduced the brain water content and the infrarct size in MCAO, improved motor abilities in the cerebral ischemia-reinfusion model of gerbils, decreased the contents of LA and LPO and increased the activities of LDH, GP X and Na + -K + -ATPase in cerebral ischemia-reinfusion model of mice. Conclusion: Pueraria compound has the function of antioxidation and protective effect on ischemic brain tissue.

关 键 词：复方葛根素 NA^+-K^+-ATP酶 实验研究 损伤保护 谷胱甘肽过氧化物酶 脑缺血再灌注损伤 全脑缺血再灌注 动脉栓塞模型 脑含水量 乳酸脱氢酶 过氧化脂质 大脑中动脉 脑梗死面积 缺血脑组织 保护作用 动物模型 梗塞范围 卒中指数 

分 类 号：R285.5[医药卫生—中药学] R994.5[医药卫生—中医学]