心力衰竭患者心肌组织β_1、β_2、β_3受体mRNA表达改变与心功能的关系  

The relationship between expressions of β_1-,β2-,β _3-adrenoceptor mRNA of myocardium and cardiac function in patients with heart failure

作　　者：李振魁[1] 祝善俊[1] 于林君[1] 田颖[1] 周裔忠[1] 王江[1] 

机构地区：[1]中国人民解放军第三军医大学新桥医院心内科

出　　处：《中华心血管病杂志》2005年第4期351-353,共3页Chinese Journal of Cardiology

摘　　要：目的　探讨不同程度心力衰竭(心衰)患者心肌组织β1、β2、β3 受体mRNA表达的变化及其与心功能的关系。方法　应用逆转录聚合酶链反应方法检测24例瓣膜置换术的心衰患者和5例健康对照者心肌组织β1、β2、β3 受体mRNA表达。结果　心衰时β1 受体mRNA表达减少,心衰程度越重表达越少;β2 受体表达在不同程度心衰患者之间改变差异无统计学意义;β3 受体表达增多,心衰程度越重表达越多。结论　心衰时β1 受体下调,而β3 受体上调,心肌组织β受体mRNA的变化与心功能密切相关。Objective To investigate the alteration of expressions of β 1-,β 2-,β 3-adrenoceptor mRNA in human myocardial tissue and the relation between their expressions and cardiac function in patient with heart failure. Methods The mRNA expressions of β 1-,β 2- and β 3-adrenergic receptors in myocardial tissue were analyzed by using the reverse transcriptase-polymerase chain reaction in 24 patients with heart failure of valvular heart disease and 5 control subjects.Results β 1-adrenergic receptor mRNA expressions in myocardium were significantly lower in patients with heart failure than those in control subjects, and progressively reduced with aggravation of heart function. By contrast, β 3-adrenoceptor mRNA expressions were significantly higher in patients with heart failure than those in controls, and progressively elevated with aggravation of cardiac function. No difference was observed in β 2-adrenergic receptor among all groups.Conclusion The changes of β-adrenergic receptor mRNA expression are associated with the severity of heart failure.

关 键 词：mRNA表达 心肌组织 Β3受体 心力衰竭患者 心功能 β2 聚合酶链反应方法 受体MRNA 不同程度 心衰患者 心衰程度 受体表达 瓣膜置换术 方法应用 表达减少 受体下调 逆转录 统计学 

分 类 号：R541.6[医药卫生—心血管疾病]