血管紧张素II受体拮抗剂对老年高血压患者大动脉缓冲功能的影响  

Effects ofangiotensin IIreceptorantagonism on large artery buffering function in elderly patients with essentialhypertension

作　　者：张志勉[1] 梁济乐[1] 高海青[1] 米丰花[1] 高西美[1] 陈珉[1] 

机构地区：[1]山东大学齐鲁医院健康体检中心,山东济南250012

出　　处：《山东大学学报（医学版）》2005年第4期318-320,共3页Journal of Shandong University:Health Sciences

摘　　要：目的:探讨血管紧张素II受体拮抗剂氯沙坦对老年高血压患者大动脉缓冲功能的影响。方法:口服氯沙坦治疗原发性高血压患者108例,其中男性85例,女性23例,平均年龄(66.48±5.16)岁,应用自动脉搏波传导速度测定仪检测治疗前和治疗3个月后患者的颈动脉-股动脉脉搏波传导速度(PWV),以判断其大动脉缓冲功能。结果:与治疗前相比,治疗3个月后患者的收缩压和舒张压显著降低(P=0.0022,P=0.0081);颈动脉-股动脉PWV显著降低[(13.60±2.31)m/svs(11.89±2.11)m/s,P=0.0416]。结论:氯沙坦不仅能良好地控制血压,亦能明显改善大动脉缓冲功能。O bjective:To evaluate the effectoflosartan,an angiotein Ⅱ receptorantagonist,on large arterialbuffering function in elderly patients with hypertension.M ethods: One hundred and eightpatients,of them 85 m ale and 23 fem ale,m edian aged (66.48 ± 5.16)years were given losartan 50 m g per day.The carotid- fem oralartey pulse wave velocity (PW V)m easurem ents were undergone in the subjects before treatm entand 3 m onthsaftera treatm ent.R esults:Three m onthsaftertreatm ent,the systolic and diastolic blood pressure values were significantly reduced (P=0.002 2,P=0.008 1),and carotid-fem oralartery PW V was significantly decreased [(13.60 ± 2.31)m/svs ( 11.89 ± 2.11 ) m/s , P=0.041 6]. C onclusion:Losartan isan effective anti鄄hypertensive drug, and can im prove large artery buffering function in patientswith essentialhypertension.

关 键 词：氯沙坦 高血压 血管紧张素Ⅱ受体拮抗剂 动脉 

分 类 号：R544.1[医药卫生—心血管疾病]