川崎病患儿血清可溶性白细胞介素-2受体和白细胞介素-6的变化及意义  

Clinical value and the serum levels of soluble interleukin-2R and interleukin-6 in patients with Kawasaki disease

作　　者：洪华[1] 邓君[1] 张玲英[1] 叶长宁[1] 赖德明[1] 

机构地区：[1]四川省人民医院检验科,成都610072

出　　处：《中华风湿病学杂志》2005年第5期297-299,共3页Chinese Journal of Rheumatology

摘　　要：目的探讨血清可溶性白细胞介素-2受体(sIL-2R)和白细胞介素-6(IL-6)水平在川崎病(K D)患儿中的变化,及其在发病中的作用。方法采用酶联免疫吸附试验(ELISA)双抗夹心法测定血清sIL-2R和IL-6水平;利用德灵BN ProSpec特种蛋白分析仪检测血清超敏C反应蛋白(hs-CRP)水平。结果30例KD患儿大剂量丙种球蛋白静脉滴注前(静丙前)和滴注后(静丙后)血清slL-2R和hs-CRP水平与对照组比较差异均有统计学意义(P<0.01),静丙前和静丙后比较差异有统计学意义(P<0.01);静丙前KD患儿血清IL-6和对照组比较差异有统计学意义(P<0.01);KD患儿血清slL-2R与hs-CR P水平呈正相关(r=0.6,P<0.01),静丙前K D患儿血清IL-6和hs-CRP呈正相关(r=0.68,P<0.01)。结论血清IL-6和slL-2R参与了川崎病的发生,它们可作为判断预后、评估患儿免疫功能状况的参考指标。Objective To explore the change of serum sIL-2R and IL-6 levels in patients with Kawasaki disease (KD) and its role in the pathogenesis. Methods The serum slL-2R and IL-6 were detected by sandwich ELISA. The serum hs-CRP level was measured by DADE BEHRING BN ProSpec. Results The serum levels of sIL-2R and hs-CRP in KD before and after high-dose intravenous gama globulin(IVIg) were significantly higher than in healthy controls (P<0.01). The pre-IVIg serum levels of sIL-2R and hs-CRP were significantly higher than the post-IVIg (P<0.01). The pre-IVIg serum level of IL-6 was significantly higher in KD than in healthy controls (P<0.01). There was positive correlation between slL-2R and hs-CRP (r=0.6, P<0.01) in KD. There was positive correlation between IL-6 and hs-CRP in the pre-IVIg of KD (r=0.68, P<0.01). Conclusion The results suggest that both IL-6 and sIL-2R are all involved in the pathogenesis of KD. They can be used as markers for evaluation the prognosis and immune function of children with KD.

关 键 词：血清可溶性白细胞介素-2受体 白细胞介素-6 川崎病 酶联免疫吸附试验(ELISA) 患儿 血清SIL-2R 血清超敏c反应蛋白 血清IL-6 大剂量丙种球蛋白 hs-CRP SLL-2R 分析仪检测 双抗夹心法 统计学 特种蛋白 静脉滴注 判断预后 

分 类 号：R725.4[医药卫生—儿科]