川芎嗪对兔急性心肌梗死血运重建后心肌“无复流”现象的影响  

The Effect of Ligustrazine on the No-reflow Phenomenon after Restoration of Coronary Blood Flow in Rabbits with Experimental Acute Myocardial Infarction

作　　者：王海涛[1] 杨军[1] 贺岩松[2] 毛庆民[2] 方毅民[1] 王新民[2] 李燕玲[2] 葛淑晶[2] 

机构地区：[1]青岛大学医学院附属烟台毓磺顶医院,山东烟台264000 [2]中国人民解放军107中心医院

出　　处：《中国微循环》2005年第2期82-84,91,共4页Journal of Chinese Microcirculation

摘　　要：目的观察川芎嗪对兔急性心肌梗死再灌注后心肌“无复流”现象的影响。方法新西兰大白兔45只。随机分为川芎嗪组(Ⅰ组)、尼可地尔组(Ⅱ组)、生理盐水对照组(Ⅲ组),每组15只。结扎冠状动脉左心室后支90min,切断结扎线后各组分别静滴川芎嗪、尼可地尔和生理盐水120min。观察指标:①左心室的心肌无复流面积和心肌梗死面积;②药物干预前后心电图ST段抬高程度,以相关导联ST段抬高指数(∑STI)表示。结果Ⅰ组和Ⅱ组的心肌无复流面积、心肌梗死面积以及再灌注120min时∑STI均小于Ⅲ组,Ⅰ组和Ⅱ组比较差异无显著性。结论川芎嗪可减少兔心肌梗死再灌注后心肌无复流面积和心肌梗死面积,减轻心肌损伤,且效果与尼可地尔相当。Objective To explore the effect of Li qustrazine on the no-reflow phenomenon in rabbits undergoing acute coronary artery occlusion-reperfusion.Methods 45 New Zealand white rabbits were randomly assigned to one of the following three groups: groupⅠ(Ligustrazine ,n=15), groupⅡ(Nicorandil,n=15),groupⅢ(NaCL salt solution,NS,n=15). Rabbit's acute ischemia-reperfusion model was carried out by ligation of left post coronary descending artery and removing the ligation after occlusion of blood flow for 90 minutes, followed by 120 minutes of reperfusion. Ligustrazine, Nicorandil and NS were given intravenously, respectively. The ST-segment changes of electrocardiogram by the time of 120 minutes after reperfusion (expressed as ∑STI)were observed. The no-reflow area(NRA) and the myocardial infarcted area (MIA)were determined by thioflavin S and TTC staining,respectively.Results Ligustrazine and Nicorandil both resulted in a significant reduction in NRA, MIA, and ∑STI,in comparison with control animals, while there is no significant difference in the effects between the two groups.Conclusions Ligustrazine can improve no-reflow phenomenon and alleviate myocardial injury in rabbits with experimental acute coronary artery occlusion-reperfusion,its effects are similar to those of nicorandil.

关 键 词：心肌无复流 川芎嗪 尼可地尔 急性心肌梗死 

分 类 号：R944.12[医药卫生—药剂学] R542.22[医药卫生—药学]