卡托普利预治疗对兔缺血-再灌注心肌的保护作用  

Myocardial protective effects of pretreatment with captopril on ischemia-reperfusion myocardium in rabbits

作　　者：胡名松[1] 胡建国[1] 周新民[1] 冯耀光[1] 王晖[1] 杨进福[1] 

机构地区：[1]中南大学湘雅二医院胸心外科,长沙410011

出　　处：《中南大学学报（医学版）》2005年第2期211-214,共4页Journal of Central South University ：Medical Science

摘　　要：目的:探讨用卡托普利预治疗对动脉粥样硬化兔心肌缺血再灌注损伤的影响。方法: 32只新西兰大白兔随机用正常饲料、高胆固醇饲料及高胆固醇加卡托普利饲料喂养10周,制成急性心脏缺血再灌注模型,测定心肌梗死面积、心肌细胞超微结构的改变及不同实验阶段血浆内皮素(ET)及一氧化氮(NO)含量的变化。结果:与卡托普利加胆固醇组比较,胆固醇组内皮素浓度显著性增高,NO浓度显著性降低;卡托普利加胆固醇组心肌细胞超微结构结构破坏及心肌梗死面积明显小于对照组和胆固醇组。结论:动脉粥样硬化兔心脏缺血再灌注前用卡托普利预治疗可减轻心肌缺血再灌注损伤。Objective To investigate the effect of pretreatment with captopril on myocardium ischemia-reperfusion injury in atherosclerotic rabbits. Methods Thirty-two New Zealand white rabbits were assigned randomly to the nomally feed group,cholesterol-feed (CF) group, and cholesterol food plus captopril group (cap-feed group),which were fed for 10 weeks. We examined the changes in the size of the infarct and changes in the myocardium ultrastructure resulting from coronary ischemia/reperfusion.Levels of endothelin (ET) and nitic oxide (NO) were measured in the different experiment stages. Results The ET levels significantly increased and the content of NO significantly decreased in the CF group compared with those of the cap-feed group.The ultrastructure of myocardium cell was slightly destroyed and the infarct size was significantly smaller in the cap-feed group than the normally feed rabbits and CF rabbits. Conclusion The long-term captopril treatment can lighten the severity of myocardial injury produced by coronary ischemia/reperfusion.

关 键 词：卡托普利 缺血-再灌注心肌 预治疗 心肌缺血-再灌注损伤 保护作用 心肌细胞超微结构 血浆内皮素(ET) 动脉粥样硬化 心肌梗死面积 新西兰大白兔 高胆固醇饲料 再灌注模型 心脏缺血 一氧化氮 实验阶段 NO浓度 显著性 对照组 

分 类 号：R96[医药卫生—药理学]