柴芪颗粒抗菌及保肝作用研究  

Effects of CQKL on Liver Protection, Antibacterial Action and Immunity Function in Mice

作　　者：时维静[1] 李立顺[1] 俞浩[1] 刘娟[2] 

机构地区：[1]安徽技术师范学院,凤阳233100 [2]中国药科大学,南京210009

出　　处：《畜牧兽医学报》2005年第5期502-505,共4页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：安徽省教育厅资助项目(2004KJ084)

摘　　要：为探讨柴芪颗粒的保肝、体外抗菌作用和对小鼠免疫功能的影响,分别采用四氯化碳(CCl4)和D 氨基半乳糖(D GalN)诱导的小鼠肝损伤模型,给予不同剂量的柴芪颗粒(15、10、5 g/kg体重),测定血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)的活性和肝组织谷胱甘肽(GSH)的含量。研究表明柴芪颗粒对四氯化碳(CCl4 )及D 氨基半乳糖(D GalN)所引起的小鼠肝损害有明显的保护作用,对血清ALT、AST活性升高有明显的降低作用(P<0.01),减少了CCl4 肝损伤小鼠戊巴比妥钠的睡眠时间;并能明显提高小鼠网状内皮系统的吞噬功能,体外试验有一定抑菌作用。可见柴芪颗粒具有抗菌、保肝和提高免疫功能的作用。In order to study the effects of Chaiqikeli (CQKL) on liver protection, antibacterial action and immunity function, hepatic injury models were established by injecting carbon tetrachloride (CCl_4)and D-galactosamine (D-GalN)into mouse and then the different dose of CQKL were given respectively. The activity of ALT and AST in the serum, the contents of glutathione (GSH) in liver homogenate from all mouse were determined. It is suggested that CQKL could significantly protect liver from CCl_4 and D-GalN injury, lower the activity of enzyme ALT, AST in serum, shorten the sleep duration induced by embuter in CCl_4 damaged mice,improve the phagocytic function of reticuloendothelial system in mice and inhibit bacterial in vitro. CQKL have the antibacterial,liver protection and immunological enhancement effects.

关 键 词：颗粒 保肝作用 体外抗菌作用 免疫功能 四氯化碳 谷丙转氨酶 谷草转氨酶 戊巴比妥钠 损伤模型 谷胱甘肽 保护作用 降低作用 睡眠时间 CCL4 吞噬功能 抑菌作用 体外试验 半乳糖 小鼠 肝组织 肝损害 ALT AST 肝损伤 氨基 

分 类 号：S859.796[农业科学—临床兽医学] TS272.51[农业科学—兽医学]