肝富集的转录因子与细胞色素P450基因的表达调控  

Regulation of cytochrome P450 genes by liver-enriched transcription factors

作　　者：诸葛坚[1] 余应年[1] 

机构地区：[1]浙江大学医学院病理生理学教研室,浙江杭州310031

出　　处：《中国病理生理杂志》2005年第5期1026-1029,共4页Chinese Journal of Pathophysiology

基　　金：973项目(No.2002CB512901);国家自然科学基金项目(No.39770868);浙江省自然科学基金项目(No.397490)资助

摘　　要：Cytochrome P450 (CYP) is a complex gene superfamily of proteins that metabolizes a myriad of endogenous and exogenous substrates. Liver-enriched transcription factors (LETF) play a role in the constitutive and tissue-specific expression of hepatic genes. In this review, six families of LETF that play a role in the tissue-specific, developmental, sexual and temporal regulation of CYP are discussed.Cytochrome P450 (CYP) is a complex gene superfamily of proteins that metabolizes a myriad of endogenous and exogenous substrates. Liver-enriched transcription factors (LETF) play a role in the constitutive and tissue-specific expression of hepatic genes. In this review, six families of LETF that play a role in the tissue-specific, developmental, sexual and temporal regulation of CYP are discussed.

关 键 词：细胞色素P450 肝富集的转录因子 肝细胞核因子 表达 

分 类 号：R97[医药卫生—药品]