Synthesis and characterization of nanoscale magnetic drug-inorganic composites  

作　　者：SUNHui ZHANGHui DavidG.Evans DUANXue 

机构地区：[1]MinistryofEducationKeyLaboratoryofScienceandTechnologyofControllableChemicalReactions,BeijingUniversityofChemicalTechnology,Beijing100029,China

出　　处：《Chinese Science Bulletin》2005年第8期752-757,共6页

基　　金：supported by the National Natural Science Foundation of China(Grant No.90306012).

摘　　要：The synthesis by direct coprecipitation and characterization of captopril (Cpl) and 5-aminosalicylic acid (5-ASA) intercalated ZnAl layered double hydroxides coated on MgFe2O4 magnetic core particles are reported. Powder XRD analysis shows the well-defined crystallite structure of the composites. TEM and XPS results reveal that a core-shell structure involving a drug-LDHs layer coated on MgFe2O4 particles is formed through Zn-O-Mg and/or Al-O-Mg link- ages. VSM measurements demonstrate that the novel mag- netic drug-inorganic composites possess considerable mag- netization.The synthesis by direct coprecipitation and characterization of captopril (Cpl) and 5-aminosalicylic acid (5-ASA) intercalated ZnAl layered double hydroxides coated on MgFe2O4 magnetic core particles are reported. Powder XRD analysis shows the well-defined crystallite structure of the composites. TEM and XPS results reveal that a core-shell structure involving a drug-LDHs layer coated on MgFe2O4 particles is formed through Zn-O-Mg and/or Al-O-Mg linkages. VSM measurements demonstrate that the novel magnetic drug-inorganic composites possess considerable magnetization.

关 键 词：磁性指标药物 锌铝分层 氢氧化物 沉淀物 

分 类 号：R96[医药卫生—药理学]