防晕船口服液及抗晕船口服液预防晕船的效果观察  

Clinical observation of the sea-sickness prophylactic effect of “anti-sick syrup” and “prevent-sick syrup”

作　　者：侯建萍[1] 黄明方[1] 于西全[2] 林洁[1] 杨烨[1] 盖晓波[1] 

机构地区：[1]南京军区福州总医院心内科,福州350025 [2]南京军区福州总医院药剂科,福州350025

出　　处：《解放军医学杂志》2005年第5期446-448,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：目的观察自制“抗晕船口服液”及“防晕船口服液”海上预防晕船的效果。方法在登陆艇上将986名首次出海出现不同程度晕船症状的志愿者分为4组,于开船前半小时分别服用安慰剂(对照组)、防晕口服液(A组)、抗晕口服液(B组)、防晕口服液+抗晕口服液(C组),记录受试者出现的晕船症状并进行统计学分析。结果4组均有预防晕船效果,对照组预防晕船作用显著低于其余3组,C组预防晕船作用明显高于A组和B组,各组间副作用无显著差别。各组对低、中敏受试者均有不同程度的抗晕船效果,但对照组明显低于其他各组;在高敏受试者中,对照组无抗晕船效果;在中、高敏受试者中,C组抗晕船的有效率、保护率明显高于A组和B组。结论抗晕船口服液及防晕船口服液具有明显的预防晕船作用,两者联用效果更佳。Objective To observe the preventive effect against sea-sickness of “anti-sick syrup” and “prevent-sick syrup” on voyage at sea. Methods A double-blind controlled trial was carried out in landing craft. 986 volunteers unaccustomed to sailing in their fist voyage at sea were divided into four groups, control group and group A to C, with ingestion, half an hour before setting sail, of placebo syrup, “anti-sick syrup”, “prevent-sick syrup” and “anti-sick syrup” plus “prevent-sick syrup”, respectively. The symptoms of seasickness were then recorded. Results The prophylactic effects have shown in all the groups. However, the effects shown in control group were significantly less than that in other groups (P<0.01), and in group C the effect was clearer than in group A and group C (each P<0.01). There was no significant difference of side effects among all groups. Subgroup analysis revealed that in all the four groups the testees with low and medium sea-sickness susceptibility, have got protection against sea-sickness in varying degrees, while the placebo showed a less sea-sickness prophylactic effect than the other administrations. In the testees with high sea-sickness susceptibility, however, placebo showed no effect on preventing sea-sickness. The sea-sickness prophylactic effects of group C was superior to group A and group B in medium and high sea-sickness susceptibility testees. Conclusions The “anti-sick syrup” and “prevent-sick syrup” were effective in preventing sea-sickness and the combined administration provided better protection without notable side effects.

关 键 词：晕动病 茶苯海明 山莨菪碱 生姜 临床研究 

分 类 号：R837[医药卫生—航空、航天与航海医学]