仿生脉冲电磁场预防性治疗对大鼠骨生物力学性能变化的影响  

Preventive effect of bionics-pulsed electromagnetic field on biomechanical property of bone

作　　者：叶青[1] 谭祖键[1] 刘乐斌[1] 赵瑛[1] 

机构地区：[1]第三军医大学西南医院骨科,重庆400038

出　　处：《第三军医大学学报》2005年第10期991-993,共3页Journal of Third Military Medical University

摘　　要：目的　观察仿生脉冲电磁场(bionicspulsedelectromagneticfields ,BEMF)预防性治疗对骨生物力学变化的影响。方法　本实验取3 2只3月龄雌性Wistar大鼠,随机分成4组:正常对照组(A组) 8只,地米组(B组) 8只,降钙素组(C组) 8只,电磁场组(D组) 8只。A组作常规喂养,同时给予注射等量生理盐水,B组仅给予地米注射(1mg/kg ,肌注,2次/周) ,D组及C组在给予地塞米松(1mg/kg ,肌注,2次/周)的同时分别给予电磁场照射(1h/d)及降钙素(2IU/kg ,皮下注射1次/d)预防性治疗,8周后观察生物力学性能实验结果。结果　BEMF预防性治疗后,D组较B组大鼠腰椎、股骨的结构力学(最大位移、最大载荷、能量)和材料力学(最大应力、最大应变、弹性系数)均明显有改善(P <0 0 5 ,P <0 0 1)。结论　仿生脉冲电磁场预防性治疗有预防大鼠骨生物力学性能下降的作用。Objective To study the protective effect of bionics-pulsed electromagnetic field (BEMF) on the biomechanical property of the bones of Wistar rats. Methods Thirty-two 3-month-old female Wistar rats were divided into 4 groups (n=8 in each group). The 8 rats of group A (the control) were treated normally and received injections of saline in the same amount of drugs for the rats of other 3 groups. The rats of group B received injections of desamethasone (1 mg/kg, 2 intramuscular injections/week). The rats of groups C and D received injections of desamethasone in the same procedure as that of group B. In addition, the rats of group C received daily subcutaneous injections of calcitonin in the dosage of 2 IU/kg and those of group D were irradiated with BEMF once daily. The results of the 3 kinds of therapeutic procedures were observed 8 weeks later. Results After the irradiation of BEMF, the biomechanical parameters of the lumbar vertebrae and the femur were far higher in the rats of group D than in those of group B. Conclusion BEMF irradiation is effective to prevent the decrease of biomechanical properties of the bones of the rats.

关 键 词：仿生脉冲电磁场 生物力学性能 预防性治疗 

分 类 号：R322.71[医药卫生—人体解剖和组织胚胎学] R339.57[医药卫生—基础医学]