微血管内血栓形成与参芪脑保颗粒的预防作用  

Preventive effect of shenqi naobao granule on microvascular thrombosis

作　　者：杜卫[1] 刘育英[2] 赵秀梅[2] 尹岭[3] 

机构地区：[1]解放军第二一○医院神经内科,辽宁省大连市116021 [2]解放军总医院微循环室,北京市100853 [3]解放军总医院神经信息中心,北京市100853

出　　处：《中国临床康复》2005年第15期126-127,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:研究中药参芪脑保颗粒对大鼠肠系膜微血管内血栓形成的预防作用。方法:实验于2001-09/12在解放军总医院微循环实验室进行。将24只Wistar大鼠随机分为实验对照组和参芪脑保预防组,分别给予饮用水及参芪脑保颗粒灌胃,连续5d,于第6天用光化学法制成肠系膜血栓模型,观察光照后微血管内血栓形成的时间、不同时间点血栓形成的大小及血栓占管腔的面积比。结果:参芪脑保预防组比实验对照组血栓出现时间晚;血栓的大小在光照后1min(15.39±6.54)×100μm2,10min(22.28±7.84)×100μm2也较对照组小(17.05±2.45),(25.45±9.12)×100μm2,差异有显著性意义(P<0.05),参芪脑保预防组血栓占管腔的面积比在光照后1min(38.10±13.24)%,10min(52.09±17.12)%,均较实验对照组小(42.0±17.87)%,(56.63±14.62)%,P<0.05。结论:参芪脑保颗粒对大鼠肠系膜微血管内血栓形成有预防作用。AIM:To study the preventive effect of shenqi naobao granule on mesentery microvascular thrombosis in rats. METHODS:The experiment was performed in the Laboratory of Microcirculation,General Hospital of Chinese PLA between September and December 2001.Totally 24 rats were randomly divided into control group and shenqi naobao group.Water and shenqi naobao were poured into stomach continuously for 5 days.The models of mesentery microvascular thrombosis were established with photochemical method at the sixth day;meanwhile,the time of the microvascular thrombosis,size of the thrombosis in different time and the ratio of the area of thrombosis were observed. RESULTS:The thrombosis appeared in shenqi naobao group later than in control group. The size of thrombosis [(15.39±6.54) ×100 μm2,(22.28±7.84)×100 μm2] was smaller than that in control group after 1 minute and 10 minutes[(17.05±2.45)×100 μm2,(25.45±9.12) ×100 μm2], and there was significant difference(P < 0.05).The ratio of the area of thrombosis[(38.10±13.24)%,(52.09±17.12)%] was smaller than that in control group[(42.0±17.87)%,(56.63±14.62)%] after induced by photochemistry for one and ten minutes(P< 0.05). CONCLUSION:Shenqi naobao granule is effective in the prevention of mesentery microvascular thrombosis.

关 键 词：微血管内血栓形成 参芪脑保颗粒 预防作用 WISTAR大鼠 大鼠肠系膜 解放军总医院 对照组 血栓模型 光化学法 不同时间 出现时间 实验室 微循环 饮用水 光照 显著性 面积 管腔 

分 类 号：R543[医药卫生—心血管疾病] R285.5[医药卫生—内科学]