参麦注射液改善充血性心力衰竭患者的心脏功能和免疫功能  

Shenmai parenteral solution for improving the cardiac and immunological functions of patients with congestive heart failure

作　　者：钮炜西[1] 华宁[1] 齐帜[1] 

机构地区：[1]解放军总医院第三○九临床部心血管内科,北京市100091

出　　处：《中国临床康复》2005年第15期142-144,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:研究参麦注射液治疗对充血性心力衰竭患者心脏功能及免疫功能的影响。方法:选择2002-03/2004-06在解放军总医院心血管内科住院的患者58例,心功能分级为2～4级,均自愿参加研究。将纳入患者随机(隐蔽分配)分为2组:西医组28例,男15例,女13例;参麦组30例,男17例,女13例。西医组给予常规西医治疗。参麦组在常规西医治疗的同时,加用参麦注射液静脉(30mL加入液体)滴注,1次/d,治疗3周。两组治疗前后均采血测定IgG,IgA,IgM和T细胞亚群,同时计算心功能指数,采用多普勒超声测定左室射血分数。结果:按意向处理分析,纳入结果分析心力衰竭患者58例。①心功能指数:参麦组和西医组治疗后(2.83±0.65,2.43±0.78)明显高于治疗前(1.87±0.68,1.75±0.75)(t=3.687,3.154,P<0.05);参麦组治疗后明显高于西医组治疗后(t=2.948,P<0.05)。②左室射血分数:西医组和参麦组治疗后(46.8±6.6)%,(52.7±11.1)%明显高于治疗前(39.6±10.3)%,(38.5±11.1)%(t=3.687,3.154,P<0.05);参麦组治疗后高于西医组治疗后(t=2.948,2.948,P<0.01)。③CD4及CD4/CD8与IgG,A,M数据变化:参麦组治疗后CD4,CD4/CD8,IgG,IgA,IgM(36.8±4.1)%,1.32±0.17,(11.38±2.04),(1.96±0.22),(1.34±0.33)g/L与治疗前(29.8±2.4)%,1.12±0.20,(14.41±2.46)。AIM:To investigate the influence of Shenmai parenteral solution on the cardiac and immunological function of patients with congestive heart failure (CHF). METHODS:Fifty-eight inpatients, whose New York Heart Association (NYHA) classification of cardiac function was grade 2 to 4, were selected from Department of Cardiology, General Hospital of Chinese PLA between March 2002 and June 2004, and they all took part in the study voluntarily. All the patients were randomly divided (coveredly allocated) into western medicine group (n=28, 15 males and 13 females) and Shenmai group (n=30, 17 males and 13 females).All the patients received regular western therapy, besides those in the Shenmai group were treated with venous drip injection of Shenmai parenteral solution (30 mL added to liquid), once a day for 3 weeks. Blood was drawn before and after treatment for determinations of immunoglobulin G, A and M (IgG, IgA, IgM) and T cell subgroup, meanwhile cardiac index was calculate, and left ventricular ejection fraction (LVEF) was detected with Doppler ultrasound. RESULTS:According to intention-to-treat (ITT) analysis, 58 CHF patients were involved in the analysis of results. ①The cardiac indexes in theShenmai group and western medicine group after treatment (2.83±0.65,2.43±0.78) were obviously higher than those before treatment (1.87±0.68,1.75 ±0.75) (t=3.687, 3.154,P< 0.05), and it was markedly higher after treatment in the Shenmai group than in the western medicine group (t =2.948,P< 0.05). ②LVEF in the Shenmai group and western medicine group after treatment [(46.8±6.6)%, (52.7±11.1)%] were obviously higher than those before treatment [(39.6±10.3)%,(38.5±11.1)%](t=3.687,3.154, P< 0.05), and it was remarkably higher after treatment in the Shenmai group than in the western medicine group (t=2.948,2.948,P< 0.01). ③In the Shenmai group, CD4, CD4/CD8,IgG,IgA and IgM after treatment were [(36.8±4.1)%, 1.32±0.17, (11.38±2.04),(1.96±0.22),(1.34±0.33)g/L], compared with those before treatment [(29.8±2.4)%,1.1

关 键 词：充血性心力衰竭患者 参麦注射液 免疫功能 心脏功能 CD4/CD8比值 左室射血分数 多普勒超声测定 心功能指数 解放军总医院 意向处理分析 西医治疗 治疗后 心血管内科 心功能分级 IgG T细胞亚群 CD4细胞 采血测定 治疗前后 

分 类 号：R259.416.1[医药卫生—中西医结合] R259.414[医药卫生—中医内科学]