哮喘患者血浆白细胞介素-18水平测定及其临床意义的研究  

Determination of plasma interleukin-18 levels and its clinical value in asthma cases

作　　者：李燕[1] 马涛[1] 陈青[1] 刘卓拉[2] 张士勖[3] 

机构地区：[1]山西医科大学第二医院急诊科,030001 [2]山西医科大学第二医院呼吸科,030001 [3]山西省儿童医院检验科

出　　处：《中国药物与临床》2004年第4期277-279,共3页Chinese Remedies & Clinics

摘　　要：目的探讨白细胞介素(IL)-18在支气管哮喘发病机制中的作用。方法收集30例哮喘患者和15名健康对照者的血浆,采用酶联免疫吸附试验(ELISA)检测血浆中IL-18、IL-12和IL-13的水平。结果哮喘组血浆IL-18、IL-13水平明显高于对照组,IL-12水平则显著低于对照组,差异有显著性(P<0.01)。哮喘组IL-18和IL-13呈显著正相关(P<0.05)。结论IL-18可能参与了哮喘的发病过程,它通过调节Th1/Th2的活性及细胞因子的产生,在哮喘的发病过程中发挥作用。Objective To explore the role of interleukin(IL)-18 in the pathogenesis of asthma.Methods Plasma from 30 asthma patients and 15 healthy subjects were collected, ELISA method was used to determine the concentrations of IL-18,IL-12 and IL-13 in plasma.Results The levels of IL-18 and IL-13 in asthma group were remarkably higher than those of healthy subjects,but IL-12 level was much lower than healthy subjects in plasma.There was significant difference in statistics(P<0.01).A significant correlation was found between the plasma levels of IL-18 and IL-13 in asthma group (P<0.05).Conclusion IL-18 is involved in the asthma process and plays an important role in affecting Th1/Th2 cells activity and cytokine production.

关 键 词：白细胞介素-18 酶联免疫吸附试验(ELISA) 临床意义 水平测定 患者血浆 IL-18 IL-13 TH1/TH2 IL-12 发病过程 支气管哮喘 发病机制 哮喘患者 细胞因子 发挥作用 对照组 显著性 正相关 

分 类 号：R562.25[医药卫生—呼吸系统]