小剂量碳酸锂与丙基硫氧嘧啶联合治疗甲状腺功能亢进症的近期疗效观察  

Short-term clinical effect observation on treatment of hyperthyroidism with small doses lithium carbonate and propylthiouracil

作　　者：楼时先[1] 翟春生[1] 

机构地区：[1]浙江省金华市人民医院内分泌科,321000

出　　处：《中国药物与临床》2004年第4期286-287,共2页Chinese Remedies & Clinics

摘　　要：目的碳酸锂、丙基硫氧嘧啶单独或小剂量联合治疗甲状腺功能亢进症的疗效比较。方法全部甲状腺功能亢进症病例共56例,随机分为3组:碳酸锂组17例,丙基硫氧嘧啶组19例,联合组(碳酸锂+丙基硫氧嘧啶)20例,治疗前及治疗2、4周测定血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺刺激素(TSH)及跟腱反射时间,比较3组疗效。结果3组治疗前甲状腺功能无明显差异,治疗后甲状腺功能均有明显下降,治疗2、4周时碳酸锂组、丙基硫氧嘧啶组FT3、FT4下降程度相似,联合组较另2组下降明显。结论碳酸锂能改善甲状腺功能,近期疗效与丙基硫氧嘧啶相似,联合治疗时其改善甲状腺功能效果将加强。Objective Compare the effects of single use of lithium carbonate or combined use with propylthiouracil(PTU) in small doses to treat hyperthyroidism.Methods All 56 cases of hyperthyroidism were randomised into three groups.Seventeen cases were given lithium carbonate,19 cases were given PTU,20 cases were given both lithium carbonate and PTU.All patients′thyroid functions were tested before initiating medication and 2,4 weeks after initiation to compare the medicative effects among the groups.Results Though there was no significant difference of thyroid function among the three groups before medication,it was found that significant improvements in all groups with similar decline of FT3 (free.triiodothyronine) and FT4 (free thyroxine) after 2,4 weeks of initiating med-ication.Conclusion Lithium carbonate can improve thyroid function in short term,its medicative effect is similar to propylthiouracil, conjoint use of the both will boost its effect on thyroid function improvement.

关 键 词：甲状腺功能亢进症 丙基硫氧嘧啶 联合治疗 碳酸锂 近期疗效观察 小剂量 游离三碘甲状腺原氨酸 游离甲状腺素 跟腱反射时间 甲状腺刺激素 疗效比较 功能效果 治疗前 下降 治疗后 FT3 FT4 相似 

分 类 号：R581.1[医药卫生—内分泌] R749.410.5[医药卫生—内科学]