益骨汤对去势大鼠的骨密度、骨生物力学的影响及相关分析  

Correlation of Changes between Bone Mineral Density and Biodynamics in the Experiment of Yigutang Treatimg Overiectomized Rats

作　　者：杨林 姚新苗 卢建华 陈于东 王靖 

机构地区：[1]浙江中医学院附属医院,杭州310009

出　　处：《浙江中医学院学报》2005年第3期53-55,共3页Journal of Zhejiang College of Traditional Chinese Medicine

基　　金：浙江省中医药管理局科研基金;No.2002C010

摘　　要：目的:探讨益骨汤治疗去势大鼠的骨密度和骨生物力学变化及相关性。方法:取12周龄Wistar雌性大鼠40只,随机分为A组(模型组)、B组(中药治疗组)、C组(阳性对照组)、D组(正常对照组)四组,每组10只,D组行假手术,其余3组行完整双侧卵巢摘除术。灌胃12周后,活杀各组动物,以双能X线密度测定仪测骨密度;通过三点弯曲试验,记录载荷一变形曲线,测定骨生物力学指标。结果:B组骨矿含量、骨密度明显高于A组(P<0.01),骨生物力学性能较A组得到明显改善。A、B、C三组的骨密度与最大应力成正相关(P<0.05)。结论:①益骨汤能刺激骨形成,使骨量明显增加,从而保持了原有骨结构的相对完整性,提高了骨的生物力学性能。②骨密度是影响骨生物力学性能的重要因素。Objective:To study the effects of Yigutang on bone mineral density and biodynamics and correlation between them of ovariectomixed(OVX)rats and to find out its mechanism.Methods:After 12 weeks of operation, 40 female Wistar rats were divided into 4 groups.Administer saline after ovariectomy to Group A(control),administer Yigutang after ovariectomy to Group B,administer α-D3 after ovariectomy to Group C(positive control)and administer saline after sham operation to Group D(sham-op),and sacrifice at 12 weeks of Yigutang treatment periods.Dual energy X-ray absorptiometry (DEXA) was used to measure the bone mineral density (BMD) and bone mineral contents(BMC).Bone biomechanical properties test as performed using a material testing machine.Results:After 12 weeks of Yigutang treatment,the BMD and BMC of group B were improved obviously,and the biomechanical parameters also unclined,and the changes of bone biomechanical properties were correlated with BMD in the groups A,B,C.Conclusions:①Yigutang can stimulae the bone formation and add to the bone mineral density,keep the integrity of the original bone structure and raise the biomechanical behavior.②The bone mineral density is an important factor of the biomechamical behavior of the bone.

关 键 词：去势大鼠 骨密度 骨汤 相关分析 骨生物力学性能 生物力学变化 Wistar 三点弯曲试验 阳性对照组 正常对照组 卵巢摘除术 雌性大鼠 双能X线 力学指标 骨矿含量 相关性 治疗组 12周 测定仪 正相关 骨形成 骨结构 B组 

分 类 号：R285.5[医药卫生—中药学] R681[医药卫生—中医学]