含靶向和造影双功能基的PEO的合成  

Synthesis of Bifunctional Poly(ethylene oxide) with Targeting and Contrast-medium Groups

作　　者：翟慕衡[1] 商永嘉[1] 杜宝辉[1] 胡继萍[1] 张德兴[1] 沈良骏[1] 

机构地区：[1]安徽师范大学化学与材料科学学院,芜湖241000

出　　处：《应用化学》2005年第5期517-520,共4页Chinese Journal of Applied Chemistry

基　　金：安徽省教委自然科学基金(2001kj094)资助

摘　　要：用-4胺基-N-2(-嘧啶)苯磺酰胺钠(磺胺嘧啶钠)作引发剂,引发环氧乙烷(EO)开环聚合,反应在非均相中进行,用自制的3,5-二-(N乙酰氨基)-2,4,6-三碘苯甲酰氯(泛影酰氯)作封端剂封端该反应,合成了含有靶向和造影双功能基团的聚环氧乙烷(PEO)大分子,反应在80℃下约需96h完成,产率为87%～90%。用IR、1HNMR、UV测试技术对聚合产物进行了表征,用VPO和GPC测定了聚合物的分子量及分子量分布。通过改变引发剂的用量可调节PEO的聚合度,得到不同分子量的PEO产物,引发剂用量较少时,产物的均匀性变好。所得产物的分子量范围为2692～11040,分子量分布的范围为1.195～1.704。不同分子量的PEO分子中靶向功能基含量的范围为2.13%～8.98%,造影功能基含量的范围为5.25%～21.72%。室温下的溶解度测试表明,产物易溶于水和DMSO、DMF、THF、氯仿、乙醇、吡啶、苯、甲苯、丙酮等溶剂。2-Sulfanilylpyrimidine(sulfadiazine) sodium was used to initiate the ring-opening polymerization of ethylene oxide to form sodium sulfadiazine poly(ethylene oxide)(PEO) (inhomogeneously), and the polymerization was terminated with 3,5-di-(N-acetamino)-2,4,6-triiodobenzoyl chloride to form a bifunctional PEO with a targeting and a contrast-medium group. The reaction time was about 96 h at 80 ℃. The yield was 87%～90%. The PEO was characterized with IR,~1H NMR, and UV. The PEO molecular weights were determined with VPO and GPC. The products with different molecular weights were obtained with different (amounts) of initiator in the reaction. The molecular weight distribution was narrower when a less amount of initiator was used. The molecular weight range of PEO was from 2 692 to 11 040, and the molecular weight distribution was from 1.195 to 1.704. The content ranges of sulfadiazine group and 3,5-di(N-acetamino)-2,4,6-(triiodobenzoyl) acyl group in PEO with different molecular weights were 2.13%~8.98% and 5.25%~21.72%, respectively. At room temperature, the products dissolve easily in water, DMSO, DMF, THF, chloroform, ethanol, pyridine, propanone, benzene, toluene, etc.

关 键 词：PEO 双功能基 造影 合成 分子量分布 ^1HNMR 磺胺嘧啶钠 聚环氧乙烷 引发剂 苯磺酰胺 开环聚合 苯甲酰氯 功能基团 测试技术 DMSO 产物 非均相 反应 酰氨基 封端剂 大分子 聚合物 GPC VPO 聚合度 可调节 均匀性 溶解度 

分 类 号：TQ463.54[化学工程—制药化工] TS727.2[轻工技术与工程—制浆造纸工程]