秋水仙胺半合成新方法  

A Novel Semi-synthesis Method for Demecolcine

作　　者：刘守信[1] 冯霄[1] 甄晓丽[2] 田霞[2] 

机构地区：[1]西安交通大学环境与化学工程学院,西安710049 [2]河北科技大学化学与制药工程学院

出　　处：《应用化学》2005年第5期569-571,共3页Chinese Journal of Applied Chemistry

摘　　要：Demecolcine was synthesized from colchicine in two steps. The methylation of colchicine with （iodomethane） was carried out in a THF solution of potassium t-butoxide at -20 ℃ for 4 h. The product was （isolated） on a silica gel flash column with a yield of over 78%. N-Methylcolchicine was then （hydrolyzed） in （i-propanol） and aqueous solution of sodium hydroxide under refluxing temperature to give （demecolcine）. The （overall） yield was 69%. The structures of the two products were confirmed by IR and 1H NMR.Demecolcine was synthesized from colchicine in two steps. The methylation of colchicine with (iodomethane) was carried out in a THF solution of potassium t-butoxide at -20 ℃ for 4 h. The product was (isolated) on a silica gel flash column with a yield of over 78%. N-Methylcolchicine was then (hydrolyzed) in (i-propanol) and aqueous solution of sodium hydroxide under refluxing temperature to give (demecolcine). The (overall) yield was 69%. The structures of the two products were confirmed by IR and ^(1)H NMR.

关 键 词：秋水仙胺 秋水仙碱 半合成 

分 类 号：O621.3[理学—有机化学]