苁蓉总苷对小鼠学习记忆障碍的影响  

Effects of Cistanchis Glycosides on Learning and Memory Impairment in Mice

作　　者：皋聪[1] 王传社[2] 巫冠中[1] 屠鹏飞[2] 

机构地区：[1]中国药科大学药理教研室,南京210009 [2]北京大学医学部,北京100083

出　　处：《中药新药与临床药理》2005年第3期162-164,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：科技部创新药物与中药现代化专项(编号96-910-05-248)。

摘　　要：目的观察苁蓉总苷对东莨菪碱所致的小鼠学习记忆获得障碍及亚硝酸钠所致小鼠学习记忆巩固障碍的影响。方法使用跳台法观察小鼠的学习记忆功能。连续灌胃给予苁蓉总苷30d,于实验的第29天训练,第30天测试,记录各动物的首次跳台潜伏期及5min内的错误次数。东莨菪碱模型于训练前15min腹腔注射东莨菪碱,而亚硝酸钠模型于训练后立即皮下注射亚硝酸钠。结果与东莨菪碱模型组比较,苁蓉总苷400、200mg/kg组及脑复康组潜伏期均明显延长,错误次数明显减少;苁蓉总苷100mg/kg组潜伏期亦明显延长,但错误次数只有一定程度的减少。与亚硝酸钠模型组比较,苁蓉总苷400、200mg/kg组潜伏期均明显延长,错误次数有一定程度的减少,但无统计学意义;苁蓉总苷100mg/kg组潜伏期及错误次数只有一定程度的改善;脑复康组潜伏期明显延长,错误次数显著减少。结论苁蓉总苷对东莨菪碱所致的小鼠学习记忆获得障碍及亚硝酸钠所致小鼠学习记忆巩固障碍均有明显的改善作用。Objective To observe the effects of cistanchis glycosides on scopolamine -induced impariment of learning and memory and on sodium nitrite -induced impariment of learning and memo ry consolidation in mice.Methods Step down test was performed to reflect th e learning and memory of mice.Cistan chis glycosides were administered c onsecutive-ly for 30days.The mice were trained o n the 29th day and measurements were c arried out on the 30th day .Latent period and number of errors within 5min were noted.Scopolamine was given by intr aperitoneal injection 15min before train-ing,and sodium nitrite was administered subcutaneously right after trainin g.Results(1)Compared with model mice in-duced by scopolamine,cistanchis glycosides 200and 400mg /kg together with piracetam 600mg /k g considerably in-creased latent period and decreased error times.Cistanchis glycosides100mg /kg also increased latent time but decreased error times to some extent.(2)Compared with model mice induced by s odium nitrite,cistanchis glycosides 200and 400mg /kg increased latent time significantly but had no significant effect on the error times.Cistanchis glycosides 100mg /kg decreased latent time and error time s to some extent.Conclusion Cistanchis glycosides could obviou sly improve scopo-lamine -induced impariment of learn ing and memory and on sodium nitrite -induced impariment of learning and memory in mice.

关 键 词：苁蓉总苷 小鼠 学习记忆障碍 跳台法 

分 类 号：R285.5[医药卫生—中药学]