复方丹参加血液稀释治疗心肌缺血－再灌注损伤的实验研究  

Experimental studies of isovolemic himodilutiontherapy with salvia miltiorrhiza solutions in the treat-ment of myocardiac inchemia-reperfusion injury inrabbits

作　　者：张少民[1] 陈少如[1] 陈韩秋[1] 黄邦汉[1] 唐仕雄[1] 

机构地区：[1]广东汕头大学医学院,汕头市中心医院,桂林市血液烯释研究所

出　　处：《中国危重病急救医学》1994年第2期67-69,共3页Chinese Critical Care Medicine

摘　　要：采用家兔冠脉左室支结扎４０ｍｉｎ、再灌４０ｍｉｎ，复制心肌缺血。再灌注损伤模型，观察复方丹参加血液稀释对家兔心肌缺血－再灌注损伤的影响。动物随机分为缺血对照组、单纯复方丹参治疗组、复方丹参加血液稀释治疗组。结果表明，与缺血对照组比较，复方丹参加血液稀释治疗组和单纯复方丹参治疗组均能缓解心肌缺血－再灌注损伤，使心电图抬高的ＳＴ段下降，使下降的左心室收缩压回升，使升高的血浆肌酸磷酸激酶和血浆丙二醛的含量下降，提高血浆超氧化物歧化酶的活性。结果还提示，复方丹参加血液稀释治疗组以上作用明显高于单纯复方丹参治疗组（ｐ＜０．０５～０．００１），说明复方丹参加入稀释液中可明显提高疗效。Myoocardial ischern ia and reperfusion injurywas produced in rabbits by ligation of the leftventricular branch of coronary artery for 40 minutesfollowed by reperfusion for 40 minutes.The effects ofcompound salvia miltiorrhiza(CSM)combined withhemodilution (HD)therapy on this model were ob-served.Thirty rabbits were randomly divided intothree groups :the ischemia control group(n=10),theCSM group (n=10)and the CSM+HD group(n=10).The results showed that CSM+HD therapycould ameliorate myocardiac cell damage duringmyocardiac ischemia and reperfusion.Thc results inthe CSM group and the CMS+HD group,as com-Dared with those of the ischemia control group wereas follows :The elevated S-T segment ofelectrocardiogram was decreased (p<0.005～0.001) :the decreased left ventricular systolic pressure(LVSP)was elevated(p<0.002～0.001);the elevatedplasma creatine phosphokinase (CPK) and malonicdialdehyde (MDA) were decreased(p<0.05～0.001); the superoxide dismutase(SOD)activity waselevated0 (P<0.001).The above effects in theCSM+HD group were better than those in the CSMgroup(p<0.05～0.001)which indicated that the ad-dition of CSM tO the diluted solution could markedlyincrease the therapeutic effectiveness

关 键 词：复方 丹参 心肌缺血 再灌注损伤 

分 类 号：R542.205[医药卫生—心血管疾病]