消炎痛对创伤大鼠脾脏淋巴细胞DNA合成能力及NK细胞活性的影响  

Effects of indometha cin on im munolog ic functions inrats with abdominal trauma

作　　者：丁显仲[1] 张寿熙[1] 潘永成[1] 李桦[1] 熊叔陶[1] 

机构地区：[1]同济医科大学附属协和医院

出　　处：《中国危重病急救医学》1994年第3期134-135,共2页Chinese Critical Care Medicine

基　　金：国家自然科学基金;卫生部青年基金

摘　　要：观察创伤大鼠的免疫功能变化及消炎痛对创伤大鼠的免疫功能的调节作用。结果显示：腹部创伤大鼠脾脏淋巴细胞ＤＮＡ合成能力明显下降，脾脏ＮＫ细胞活性亦明显受到抑制；应用消炎痛治疗能够明显地改善创伤大鼠脾脏淋巴细胞的ＤＮＡ合成能力，增强脾脏ＮＫ细胞活性。作者认为，消炎痛有可能成为临床上调节创伤机体免疫功能有价值的药物之一。In this article,we studied the changes of N K ac-tivity and DN A synthesis capacity of the spleniclymphocytes in rats with abdominal trauma and theeffects of indomethacin on the lymphocyte functionsof the spleen。The results showed that NK activity ofthe splenic lymphocytes in rats with abdominaltrauma was significantly depressed and the DNAsynthesis capacity obviously decreased.Indomethacincould clearly improve D N A synthesis capacity of thesplen ic lymphocytes and N K activity in rats withabodominal trauma。

关 键 词：消炎痛 创伤 免疫调节 药理 

分 类 号：R965.1[医药卫生—药理学]