慢性阻塞性肺疾病急性加重期床旁监测最大吸气流速的意义  

Significance of bedside monltoring of maximalinspiratory flow rate in the stage of cute exacerbatlonof chronic obstructive pulny,nary diseases

作　　者：张波[1] 刘树芬[1] 蒋永艳[1] 张劭夫[1] 鲁勇 

机构地区：[1]济南军区总医院呼吸内科

出　　处：《中国危重病急救医学》1994年第4期207-208,共2页Chinese Critical Care Medicine

摘　　要：对５２例慢性阻塞性肺疾病（ＣＯＰＤ）患者进行床旁最大吸气流速（ＭＩＦＲ）监测。结果：ＣＯＰＤ急性加重期ＭＩＰＲ较缓解期明显降低（Ｐ＜０．０５），后者较正常人ＭＩＦＲ亦显著降低（Ｐ＜０．０５）；急性加重期伴ＣＯ＿２潴留者ＭＩＦＲ值低于无ＣＯ＿２潴留者（Ｐ＜０．０５）。ＭＩＦＲ与ＰａＣＯ＿２呈负相关（ｒ＝－０．６２，Ｐ＜０．００５），与最大通气量（ＭＶＶ）呈正相关（ｒ＝０．６１，Ｐ＜０．００５），直线回归方程分别为：Ｙ（ＰａＣＯ＿２）＝６７．４－１４．３ＭＩＦＲ（Ｌ／ｓ），Ｙ（ＭＶＶ）＝９．８＋１９．３ＭＩＦＲ（Ｌ／ｓ）。提示：ＭＩＦＲ是准确反映肺功能损害程度的可靠指标，并能提示预后，对及时发现吸气肌疲劳，进行合理治疗有指导作用。Maximal inspiratory flow rate(MIFR)wasmonitored in 55 patients with chronic obstructivepulmonary diseases(COPD).MIFR wassignificantly decreased in the stage of acuteexacerbation of COPD as compared to that in thestage of remission(P<0.005),however it was alsosignificantly decreased in the stage of remission ofCoPD in comparison with that in the normal con-trols(P<0.005).In the stage of acute exacerbationof C O PD,MIFR was lower in patients withCO_2 retension than that in patients withoutCO_2 retension(P< 0.005).There existed a negativecorrelation between M IFR and PaCO_2( r=-0.62,P<0.005) and a positive correlation between M IFRand MVV(r=0.61,P<0.005). According to the linear regression equation,Y<PaCO_2)=67.4-14.3 MIFR(L/s),and Y(MVV)=9.8+19.3 MIFR(L/s). All these indicated thatMIFR could accurately reflect the degree of lungfunction impairment and predict the prognosis ,which might be helpful to timely detecting theexistance of inspiratory muscular fatigue and to itsReaonable treatment,

关 键 词：肺疾病 慢性阻塞性 呼吸功能试验 

分 类 号：R563.04[医药卫生—呼吸系统]