急性心肌梗塞患者血浆内皮素测定的临床意义  

Clinical significance of plasma endothelin determina-tion in patients with acute myocardial infarction

作　　者：李春盛[1] 景荣[1] 张培红[1] 李华琴[1] 马力[1] 田茹敏[1] 周苤芝 杨素红[1] 

机构地区：[1]解放军北京军区总医院急诊科,解放军北京军区总医院同位素科

出　　处：《中国危重病急救医学》1994年第5期278-280,共3页Chinese Critical Care Medicine

摘　　要：用放免方法测定了３０例急性心肌梗塞患者、２０例不稳定型心绞痛患者血浆内皮素浓度，并与４２例正常人对比。结果表明：急性心肌梗塞血浆内皮素浓度明显高于正常人和不稳定型心绞痛患者（Ｐ均＜０．００１），而不稳定型心绞痛患者与正常人间无显著性差异（Ｐ＞０．０５），这些结果有利于不稳定型心绞痛与急性心肌梗塞的鉴别。在急性心肌梗塞组，有心力衰竭者血浆内皮素比无心力衰竭者显著升高（Ｐ＜０．００１），表明血浆内皮素浓度与病情程度和预后有关。The level of plasma endothelin(ET)was deter-mined in 30 patients with acdlte myocardlal infarction(AM I)and 20 patients with unstable angina pectoris by radioimmunoassay and compared with values ofthe 42 normal controls;TheresultShowedthatplasma ET level was significantly higher in AMIgroup than that in the normal control group and thepatients with unstable angina pectoris(P<0.001),but no significant difference was showen between thegroup of unstable angina pectoris and the normalcontrol group(P>0.05).These findings were helpfulin the differentiation between unstable anginapectoris and AM I.In comparison with AM I withoutheart failure,plasma ET Ievel was significantly in-creased in AMI with heart failure(P<0.001).Tbeseresults indicated that Dlasma ET level was related tothe prognosis and severity of AM I.

关 键 词：心肌梗塞 急性 内皮素 病理 

分 类 号：R542.220.2[医药卫生—心血管疾病]