生长激素促释放剂受体配体的研究进展  

Advance in Ghrelin

作　　者：王楠[1] 刘志敏[2] 刘党生[1] 

机构地区：[1]沈阳药科大学,辽宁沈阳110015 [2]军事医学科学院生物工程研究所,北京100071

出　　处：《生物技术通讯》2005年第3期320-322,共3页Letters in Biotechnology

摘　　要：生长激素促释放剂是一种合成的小分子化合物,它通过生长激素促释放剂受体而起作用,该受体是一种新的G蛋白偶联受体。以前曾认为生长激素促释放剂受体是一种孤儿受体,直到近年来从人和鼠的胃中鉴定到Ghrelin的存在,而改变了这种看法。Ghrelin是包含28个氨基酸残基的肽,在3号位的丝氨酸位点有辛酰化基团。该肽是在X/A样细胞分泌颗粒中发现的,Ghrelin的发现表明促垂体分泌生长激素可能不止受到来自下丘脑的生长激素释放激素的调节,同时还可能受到来自胃和下丘脑的Ghrelin的调节。Growth hormone(GH) secretagogues(GHSs) are small synthetic molecules that act through a specific G-protein-coupled receptor(GPCR) called GHS-R. Until the recent identification of 'Ghrelin' from rat and human stomachs, GHS-R was an orphan receptor. Ghrelin is a 28-amino acid peptide with an essential n-octanoyl modification at Ser3. This peptide is found in the secretory granules of X/A- like cells, whose hormonal products and physiological functions have not been previously clarified. The discovery of ghrelin indicates that the release of GH from the pituitary might be regulated not only by hypothalamic GH-releasing hormone, but also by ghrelin derived from the stomach and hypothalamus.

关 键 词：释放剂 研究进展 Ghrelin 生长激素释放激素 G蛋白偶联受体 配体 小分子化合物 氨基酸残基 孤儿受体 分泌颗粒 下丘脑 丝氨酸 细胞 垂体 肽 鼠 

分 类 号：Q575.11[生物学—生物化学] O655.25[理学—分析化学]