噬菌体裂解酶研究进展  

The Progress in Bacteriophage Lysins

作　　者：李晓静[1,2] 方宏清[1] 付学奇[3] 陈惠鹏[1] 

机构地区：[1]军事医学科学院生物工程研究所 [2]吉林大学生命科学学院,吉林长春130023 [3]吉林大学生命科学学院

出　　处：《生物技术通讯》2005年第3期326-329,共4页Letters in Biotechnology

摘　　要：噬菌体裂解酶是双链DNA噬菌体所特有的细胞壁水解酶。研究表明,所有噬菌体裂解酶在结构上具有相似性,即含有2个结构域:比较保守的N端催化区和差异较大的C端特异性结合区。裂解酶的高亲和性与种属特异的细胞壁糖基有关,而后者常常是细菌存活的必要成分。所以,细菌难以产生对裂解酶的抗性。本文简要综述噬菌体裂解酶的研究进展。Bacteriophage lysins are lytic agents used by double-stranded DNA(dsDNA) phages to coordinate bacterial cell wall lysis. Many reseaches show that they have similarity in the structure, consisting of a usually well-conserved N-terminal catalytic domain fused to a largely divergent specificity or binding domain. High-affinity binding is directed towards species- or strain-specific cell wall carbohydrates that are often essential for viability, thus implying that intrinsic lysin resistance could be rare. The last progress in bacreriophage lysins were reviewed in this article.

关 键 词：研究进展 裂解酶 噬菌体 细胞壁水解酶 双链DNA 相似性 结合区 特异性 催化区 结构域 亲和性 细菌 C端 N端 

分 类 号：Q939.48[生物学—微生物学] TS143.32[轻工技术与工程—纺织材料与纺织品设计]