糖尿病肾病中转化生长因子-β_1信号转导与肾纤维化  

Relationship between transforming growth factor-β_1 signal transduction and renal fibrosis of diabetes

作　　者：汪建云[1] 印晓星[1] 

机构地区：[1]徐州医学院药学系

出　　处：《中国临床药理学与治疗学》2005年第4期371-376,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：江苏省高校自然科研基金课题 (№ 0 3KJ13 3 60 14 3 )

摘　　要：糖尿病肾病是终末期肾衰的主要原因之一,其主要病理特征为肾纤维化,转化生长因子- β1是其肾纤维化过程中的核心因子。转化生长因子 -β1下游的两条信号通路Smads、MAPK与肾纤维化过程中ECM的堆积密切相关。两种信号通路相互作用,共同促进肾纤维化的发展。真正理解它们之间的关系为糖尿病肾病的治疗提供了一个新的思路。Diabetic nephropathy is one of the leading causes of the end-stage renal failure, and its major pathologic feature is the renal fibrosis. Transforming growth factor-β_1 is a key factor in the progression of the disease. Two signal pathways, Smads and MAPK following the factor, are closely connected with extracellular matrix accumulation which leads to renal fibrosis. Smads and MAPK also have a cross talk in extracellular matrix accumulation. The relationship between the two signal pathway and ECM accumulation offers us a new therapeutic strategy for renal fibrosis of diabetes.

关 键 词：糖尿病肾病 转化生长因子-Β1 肾纤维化 SMADS MAPK 

分 类 号：R966[医药卫生—药理学]