自身免疫性甲状腺疾病伴肾小球肾炎1例报告及文献复习  

Autoimmune thyroid disease and glomerulonephritis

作　　者：黄建萍[1] 张敬京[1] 宗媛华[1] 刘景城[1] 杨霁云[1] 

机构地区：[1]北京大学第一医院儿科,北京100034

出　　处：《临床儿科杂志》2005年第5期305-308,共4页Journal of Clinical Pediatrics

摘　　要：目的探讨自身免疫性甲状腺疾病与肾小球肾炎的关系。方法通过对1例以间断浮肿、血尿、蛋白尿及突眼为主诉的患儿进行甲状腺功能、自身抗体及肾组织病理检查,并结合文献复习进行综合分析。结果13岁女孩肾脏受损表现为迁延性肾小球肾炎,肾脏病理为混合型,以膜性肾病为主;同时有甲状腺功能亢进症状,血T3、T4升高,TSH下降,甲状腺自身抗体TRAb、TGAb及TPOAb异常增高。诊为自身免疫性甲状腺疾病相关肾小球肾炎,Graves病合并桥本氏病。结论自身免疫性甲状腺疾病是继发性肾小球肾炎的原因之一,应给予充分的认识。Objective To explore the relationship of autoimmune thyroid disease and glomerulone- phritis.Methods The clinical manifestation and renal pathological data of a13-year-old girl with autoim- mune thyroid disease associated with glomerulonephritis were reviewed.Results The patient manifested with proteinuria(less than50mg/kg·d)and microscopic hematuria.The renal biopsy showed membranous nephropathy and partial glomeruli mixed proliferative changes.This patient also presented with the symp- toms of hyperthyroidism such as palpitation,excessive sweating,irritable,exophthalmas,wide pulse pres- sure,goiter,increased serum T 3 and T 4 ,decreased serum TSH and obviously elevated antibody and anti- thyroid autoimmune antibodies(anti-TSH receptor antibodies,anti-thyroglobulin antibody and anti-thyroid peroxidase antibody).Autoimmune thyroid disease associated with glomerulonephritis and Graves disease with Hashimoto thyroiditis was diagnosed.Conclusions Autoimmune thyroid disease may be one of the important causes of secondary glomerulonephritis,so,much attention should be paid.

关 键 词：自身免疫性甲状腺疾病 肾小球肾炎 临床 

分 类 号：R725.8[医药卫生—儿科]