甲状腺激素缺乏对大鼠胸腺CK19阳性上皮细胞的影响  

Effect of thyroid hormones deficiency on CK19^+ thymic epithelial cells

作　　者：张国权[1] 刘皓[1] 康亚妮[1] 陈祖培[2] 阎玉芹[2] 

机构地区：[1]天津医科大学组胚教研室,天津300070 [2]天津医科大学内分泌研究所

出　　处：《中国地方病防治》2005年第3期135-137,共3页Chinese Journal of Control of Endemic Diseases

基　　金：国家自然科学基金重点资助项目(30230330);天津医科大学科研资助项目(No.2001KY34)

摘　　要：目的探讨甲状腺激素缺乏对大鼠胸腺CK19+上皮细胞的影响。方法将断乳1月龄的Wistar大鼠分为2组:正常组饲以正常饲料,饮用自来水;低碘组饲以低碘饲料,饮用去离子水。实验3个月及6个月后,测定各组大鼠的胸腺指数、血清甲状腺激素及胸腺CK19+上皮细胞的体密度和面数密度。结果实验3个月后,低碘组大鼠的胸腺指数、T4显著降低,而CK19+上皮细胞的体密度和面数密度未见明显变化;实验6个月后,低碘组大鼠的T3、T4显著降低,胸腺CK19+上皮细胞的体密度的面数密度显著降低。结论甲状腺激素缺乏可使大鼠胸腺严重退化,CK19+上皮细胞减少。Objectives To study the influence of thymic CK19^+ epithelial cells in condition of thyroid hormones deficiency.Methods Wistar rats,1 month after stopping laction,were divided into two groups.Normal group was fed with normal-iodine diet and a tap water.Low iodine group was fed with low-iodine diet and a deionic water.Three months and six months later respectively,we measure thymic index,thyroid hormones in serum and volume density(Vv)and numerical density on area(N_A)of CK19^+ thymic epithelial cells.Results Three months later,thymic index and T_4 were decreased dramatically in low iodine group.However,the significant changes in volume density and numerical density on area of thymic CK19^+ epithelial cells were not observed.Six months later,T_3 T_4 and volume density and numerical density on area of thymic CK19^+ epithelial cells were decreased obviously in low iodine group.Conclusions Thymus degeneration and decrease of CK19^+ thymic epithelial cells were demonstrated in iodine deficiency rats,possibly due to hypothyroidism.

关 键 词：甲状腺激素缺乏 上皮细胞 CK19 Wistar大鼠 血清甲状腺激素 阳性 胸腺指数 饮用自来水 数密度 体密度 去离子水 细胞减少 低碘 正常组 实验 饲料 T4 

分 类 号：R591.1[医药卫生—内科学] R776.1[医药卫生—临床医学]