替米沙坦对肾性高血压心肌纤维化及结缔组织生长因子的影响  

Effects of telmisartan on myocardial fibrosis and expression of connective tissue growth factor in renovascular hypertensive rats

作　　者：陈智龙[1] 哈黛文[1] 汪燕舞[2] 

机构地区：[1]武汉大学中南医院心内科,湖北武汉430071 [2]武汉大学中南医院病理科,湖北武汉430071

出　　处：《现代医学》2005年第2期101-103,共3页Modern Medical Journal

摘　　要：目的　探讨替米沙坦对肾血管性高血压心肌纤维化及结缔组织生长因子(CTGF)表达的影响。方法　建立二肾一夹肾血管性高血压(2K1C- RH)大鼠模型,将实验大鼠随机分为3组:假手术组、高血压组及替米沙坦治疗组。术后4周末开始以替米沙坦3 0mg·kg-1·d-1灌胃,共8周。测量大鼠收缩压、胶原容积分数(CVF)、血管周围胶原面积(PV CA)及CTGF、转化生长因子 β1(TGF-β1)的表达。结果　与假手术组大鼠相比,高血压组的收缩压、CVF及PVCA显著增加(P <0 .0 1) ,CTGF、TGF -β1表达上调(P <0 .0 1) ;替米沙坦组与高血压组相比,心肌组织中CVF、PVCA、CTGF及TGF -β1的表达明显降低(P <0 .0 5 )。结论　替米沙坦可抑制高血压心肌纤维化,其机制可能与下调CTGF的表达有关。Objective To investigate the effects of telmisarta n on myocardial fibrosis and connective tissue growth factor(CTGF) in renovascular hypertensive (RH) rats. Methods RH models were established in 24 rats. rats w ere randomly divided into sham group, RH group and telmisartan group. Four weeks after, rats in telmisartan group were administered telmisartan 30-mg·kg -1·d -1 for 8 weeks. Systolic blood pressure (SBP) was measured. Co llagen volume fraction (CVF), perivascular collagen area(PVCA),CTGF and TGF-2? ? expression in l eft ventri cular tissue were calculated. Results Compared with sham grou p, The SBP,CVF,PVCA,CTGF and TGF-β 1 expression increased markedly in RH group (P<0.01). Compared with the RH group, CVF,PVCA, CTGF and TGF- β 1 expression decreased in RH group (P<0.05). Conclusions Telmisartan could inhibit the development of myocardial fibrosis i n renovascular hypertensive rats. It was probably related to the decrease exp ression of cardiacal CTGF.

关 键 词：结缔组织生长因子 心肌纤维化 替米沙坦 转化生长因子-β1(TGF-β1) 肾性高血压 肾血管性高血压 CTGF 高血压组 大鼠模型 二肾一夹 方法建立 实验大鼠 容积分数 血管周围 表达上调 心肌组织 收缩压 CVF 治疗组 手术 胶原 

分 类 号：R692[医药卫生—泌尿科学] R544.1[医药卫生—外科学]