合欢皮中两个新八糖苷的分离鉴定和活性研究  

Structures and Activity of Two Novel Saponins from Albiza julibrissin

作　　者：邹坤[1] 崔景荣[2] 冉福香[2] 王邠[1] 赵玉英[1] 张如意[1] 郑俊华[1] 

机构地区：[1]北京大学药学院天然药物学系 [2]北京大学药学院天然药物及仿生药物国家重点实验室,北京100083

出　　处：《有机化学》2005年第6期654-659,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20432030)资助项目.

摘　　要：从合欢皮95%乙醇提取物中分离得到2个新的八糖苷(1,2),经化学方法与光谱分析将其结构鉴定为3-O-[β-D-吡喃木糖基-(1→2)-α-L-吡喃阿拉伯糖基-(1→6)-β-D-吡喃葡萄糖基]-21-O-[(6S)-2-反式-2-羟甲基-6-甲基-6-O-β-D-吡喃鸡纳糖基-2,7-辛二烯酸基]-金合欢酸-28-O-β-D-吡喃葡萄糖基-(1→3)-[α-L-呋喃阿拉伯糖基-(1→4)]-α-L-吡喃鼠李糖基-(1→2)-β-D-吡喃葡萄糖基酯(1)和3-O-[β-D-吡喃木糖基-(1→2)-α-L-吡喃阿拉伯糖基-(1→6)-β-D-2-去氧-2-乙酰氨基吡喃葡萄糖基]-21-O-[(6S)-2-反式-2-羟甲基-6-甲基-6-O-β-D-吡喃鸡纳糖基-2,7-辛二烯酸基]-金合欢酸-28-O-β-D-吡喃葡萄糖基-(1→3)-[α-L-呋喃阿拉伯糖基-(1→4)]-α-L-吡喃鼠李糖基-(1→2)-β-D-吡喃葡萄糖基酯(2),分别命名为合欢皂苷J25(1,JulibrosideJ25)和合欢皂苷J22(2,JulibrosideJ22).1和2在体外对4种人癌细胞增殖有明显的抑制作用.Two triterpene saponins acylated with monoterpenoid were isolated from the stem barks of Albizia julibrissin. Their structures were identified as 3-O-[β-D-xylopyranosyl-(1→ 2)-α-L-arabinopyranosyl(1→ 6)-6-β-D-glucopyranosyl]-21-O-[(6S)-2-trans-2-hydroxymethyl-6-methyl-6-O-β-D-quinovopyranosyl- 2,7-octadienoyl]-acacic acid-28-O-β-D-glucopyranosyl-(1→ 3)-[α-2-arabinofuranosyl-(1→ 4)-α-L-rhomnopyranosyl-(1→ 2)-β-D-glucopyranosylester (1) and 3-O-[β-D-xylopyranosyl-(1→ 2)-α-L-arabinopyranosyl(1→ 6)-β-D-2-deoxy-2-acetamidoglucopyranosyl]-21-O-[(6S)-2-trans-2-hyqoxymethyl-6-methyl-6-O-β-D- quinovopyranosyl-2,7-octadienoyl]-acacic acid-28-O-β-D-glucopyranosyl-(1→ 3)-[α-L-arabinofuranosyl(1→ 4)]-α-L-rhamnopyranosyl-(1→ 2)-β-D-glucopyranosyl ester (2) based on chemical and spectroscopic methods, respectively, named as Julibrosides J(25) and J(22). Julibrosides J(25) and J(22) showed marked activities against four kinds of cancer cell lines in a concentration of 100 μ g/mL assayed by SRB method.

关 键 词：活性研究 分离鉴定 糖苷 葡萄糖基 乙醇提取物 阿拉伯 结构鉴定 光谱分析 化学方法 乙酰氨基 抑制作用 细胞增殖 羟甲基 金合欢 吡喃 反式 呋喃 烯酸 皂苷 酯 

分 类 号：O629.13[理学—有机化学] TQ914.1[理学—化学]