心绞痛患者纤溶活性变化的研究  

Changes of fibrinolytic system in patients with angina

作　　者：薛书峰[1] 娄书花[1] 赵建华[1] 金军[1] 

机构地区：[1]洛阳市中心医院心内科,河南洛阳市471009

出　　处：《中国心血管病研究》2005年第6期440-442,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨不同类型心绞痛患者纤溶活性变化。方法将92例心绞痛患者分为三组,稳定型心绞痛组20例,cTnT阴性的不稳定型心绞痛组47例,cTnT阳性的不稳定型心绞痛组25例。另选20例同年龄组的健康体检者为对照组。测定并比较各组血浆D-二聚体(D-dimer)和组织型纤溶酶原激活剂(t-PA)及其抑制物(PAI-1)水平。结果cTnT阴性和阳性的不稳定型心绞痛组PAI-1和D-dimer水平均较对照组升高(P<0.01),各组心绞痛患者t-PA/PAI-1较对照组降低(P<0.01)。稳定型心绞痛、cTnT阴性的不稳定型心绞痛和cTnT阳性的不稳定型心绞痛PAI-1、t-PA/PAI-1和D-dimer差异有统计学意义(P<0.01),以cTnT阳性的不稳定型心绞痛患者变化最明显,稳定型心绞痛患者变化较小。结论稳定型和不稳定型心绞痛患者纤溶活性均存在异常,cTnT阳性的不稳定型心绞痛患者变化最明显。Objective To investigate the change of fibrinolytic system in patients with angina. Methods ninety two patients with angina were divided into three groups: stable angina group (n=20), unstable anina with negative cTnT group (n=47), unstable anina with positive cTnT group (n=25). All of patients and twenty five healthy control were taken fasting blood samples for measurement of plasm D-dimer, tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1(PAI-1). Results PAI-1 and D-dimer increased in both negative cTnT unstable angina and positive cTnT unstable angina compared with control group(P<0.01=. t-PA / PAI-1 decrease in the three angina groups compared with control group(P<0.01=.There were significant difference among the three angina groups (P<0.01=. The change was notable in positive cTnT unstable angina group and lesser in negative cTnT unstable angina group . Conclusion The study suggested that the function of fibrinolytic system was insufficiency in patients with stable angina and unstable angina. The change was notable in positive cTnT unstable angina.

关 键 词：心绞痛 纤溶酶 二聚作用 

分 类 号：R543.4[医药卫生—心血管疾病]