原发性支气管肺淀粉样变三例临床分析  

Analysis of 3 cases of primary bronchial and pulmonary amyloidosis

作　　者：陈静璐[1] 徐志豪[1] 沈华浩[1] 

机构地区：[1]浙江大学医学院附属第二医院浙江大学呼吸疾病研究所,杭州310009

出　　处：《临床内科杂志》2005年第6期406-408,共3页Journal of Clinical Internal Medicine

摘　　要：目的探讨原发性支气管肺淀粉样变的流行病学、诊断、治疗和预后。方法对3例病理确诊为原发性支气管肺淀粉样变病人的临床表现、实验室检查及治疗进行分析总结。结果3例病人均有发热、咳嗽咳痰、胸闷气急,均经纤支镜活检,见均质嗜伊红物沉积于支气管粘膜下,刚果红染色阳性,经MP方案、抗菌药、手术及支持治疗后病情均明显好转。结论淀粉样变常累及呼吸系统,但临床少见,诊断依靠病理活检,目前尚无特异性治疗。Objective To discuss the epidemiology,diagnosis,treatment and prognosis of primary bronchial and pulmonary amyloidosis.Methods 3 cases of primary bronchial and pulmonary amyloidosis diagnosised by transbronchial lung biopsy(TBLB)were analyzed retrospectively.Results The most common symptoms of 3 cases were fever,cough,sputum,chest tightness and dyspnea.Their pulmonary biopsy specimens all showed that homosphere eosinophilous substance deposited under bronchial mucosa and Congo red stain were all positive.After some therapy such as MP regime,antibacterial,operation and support treatment,all the patients relieved markedly.Conclusion Amyloidosis often involved respiratory system,though it is rare in clinic.Its diagnosis relies on pathology,but there are no specific treatments so far.

关 键 词：淀粉样变 支气管 肺 活组织检查 治疗 

分 类 号：R562[医药卫生—呼吸系统]