优保津防治肺癌化疗引起的白细胞减少  

THE EFFECT OF RECOMBINANT GRANULOCYTE COLONY-STIMULATING FACTOR IN TREATMENT OF NEUTROPENIA CAUSED BY CHEMOTHERAPY

作　　者：李龙芸[1] 朱元珏[1] 于丽[1] 曹伟标[1] 马毅[1] 贾淑琴[2] 王玉洪[2] 李霞[2] 

机构地区：[1]北京协和医院内科,100730 [2]内燃机厂职工医院内科

出　　处：《中国新药杂志》1994年第1期29-32,共4页Chinese Journal of New Drugs

摘　　要：将小细胞及非小细胞肺癌病人随机分成两组,即G-CSF组(18例)和对照组(14例),观察粒细胞减少症发生率(ANC<1.0×10~9/L),平均粒细胞最低值及最低粒细胞值的持续时间。化学治疗方案为CE或COME,G-CSF组分别于化疗周期的d4、12开始用G-CSF直至d19。两组ANC最低值分别为2.0±1.0×10~9/L,1.3±0.85×10~9/L(P<.05),出现ANC最低值分别在化疗后10.5±3.8d,15.9±3.7d(P<0.001),ANC<2.0×10~9/L持续天数分别为4.5±3.4d,15.9±3.7d(P<0.001)。G-CSF组仅1例病人发生中度骨痛,另1例有失眠,因此G-CSF副反应少而轻微。Patients with cancer are randomly divided into two groups. They were assigned to receive either control or recombinant granulocyte colony-stimulating factor (G-CSF), Results showed that there were significant difference between the groups in the mean ANC nadirs (2. 0±1. 0×109/L in the G-CSF group vs 1. 3±0. 85× 109/L in the control group, P<0. 05). The times to ANC nadir in G-CSF and control groups are 10. 5 ± 3. 8 and 15. 9 ± 3. 7 days respectively and the mean durations of ANC <2. 0×109 are 4. 5±3. 4 and 7. 21±3. 8 days respectively. The ADRs of this drug are mild.

关 键 词：肺肿瘤 抗癌药 优保津 白细胞减少 

分 类 号：R979.1[医药卫生—药品]