Effects of I-tetrahydropalmatine on locomotor sensitization to oxycodone in mice  

作　　者：Yan-liLIU Jian-huiLIANG Ling-diYAN Rui-binSU Chun-fuWU Ze-huiGONG 

机构地区：[1]BeijingInstituteofPharmacologyandToxicology,Beijing100850,China [2]BeijingInstituteofPharmacologyandToxicology,Beijing100850,China//DepartmentofPharmacology,ShenyangPharmaceuticalUniversity,Shenyang110016,China [3]DepartmentofNeuropharmacology,NationalInstituteonDrugDependence,PekingUniversity,Beijing100083,China [4]DepartmentofPharmacology,ShenyangPharmaceuticalUniversity,Shenyang110016,China

出　　处：《Acta Pharmacologica Sinica》2005年第5期533-538,共6页中国药理学报（英文版）

摘　　要：Aim:Recent studies have shown that 1-tetrahydropalmatine(l-THP),an active component of Corydolis yanhusuo,can inhibit the development of the condi- tional place preference induced by opioid receptor agonists,but the effects of l- THP on locomotor sensitivity induced by opioid receptor agonists have not been documented.In the present study,the effects of l-THP on locomotor sensitization to oxycodone,which is an opioid receptor agonist,were studied.Methods:Mice treated daily for 7 d with 5 mg/kg oxycodone and challenged with the same dose after 5 days of washout showed locomotor sensitization.In order to study the effects of l-THP on locomotor sensitization induced by oxycodone,l-THP was administered at doses of 6.25,12.5,and 18.75 mg/kg,40 min prior to treatment of oxycodone.Results:l-THP per se did not affect the locomotor activity at the doses of 6.25,12.5,and 18.75 mg/kg,but could antagonize the hyperactivity in- duced by oxycodone(5mg/kg).Co-administration of l-THP(18.75 mg/kg),40 min prior to oxycodone,could inhibit the development of sensitization to oxycodone. In addition,l-THP(6.25,12.5,and 18.75 mg/kg,ig)dose-dependently prevented the expression of oxycodone sensitization.Conclusion:These results suggested that l-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization.Aim:Recent studies have shown that 1-tetrahydropalmatine(l-THP),an active component of Corydolis yanhusuo,can inhibit the development of the condi- tional place preference induced by opioid receptor agonists,but the effects of l- THP on locomotor sensitivity induced by opioid receptor agonists have not been documented.In the present study,the effects of l-THP on locomotor sensitization to oxycodone,which is an opioid receptor agonist,were studied.Methods:Mice treated daily for 7 d with 5 mg/kg oxycodone and challenged with the same dose after 5 days of washout showed locomotor sensitization.In order to study the effects of l-THP on locomotor sensitization induced by oxycodone,l-THP was administered at doses of 6.25,12.5,and 18.75 mg/kg,40 min prior to treatment of oxycodone.Results:l-THP per se did not affect the locomotor activity at the doses of 6.25,12.5,and 18.75 mg/kg,but could antagonize the hyperactivity in- duced by oxycodone(5mg/kg).Co-administration of l-THP(18.75 mg/kg),40 min prior to oxycodone,could inhibit the development of sensitization to oxycodone. In addition,l-THP(6.25,12.5,and 18.75 mg/kg,ig)dose-dependently prevented the expression of oxycodone sensitization.Conclusion:These results suggested that l-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization.

关 键 词：L-TETRAHYDROPALMATINE OXYCODONE locomotor sensitization 

分 类 号：R971[医药卫生—药品]