Distribution of cysteinyl leukotriene receptor 2 in human traumatic brain injury and brain tumors  

作　　者：HuaHU GaoCHEN Jian-minZHANG Wei-pingZHANG LeiZHANG Qiu-fuGE Hong-tianYAO WeiDING ZhongCHEN Er-qingWEI 

机构地区：[1]DepartmentofNeurosurgery,theSecondAffiliatedHospital,SchoolofMedicine,ZhejiangUniversity,Hangzhou310009//DepartmentofPharmacology,SchoolofMedicine,ZhejiangUniversity,Hangzhou310031 [2]DepartmentofNeurosurgery,theSecondAffiliatedHospital,SchoolofMedicine,ZhejiangUniversity,Hangzhou310009 [3]DepartmentofPharmacology,SchoolofMedicine,ZhejiangUniversity,Hangzhou310031 [4]DepartmentofPathology,theFirstAffiliatedHospital,SchoolofMedicine,ZhejiangUniversity,Hangzhou310003,China

出　　处：《Acta Pharmacologica Sinica》2005年第6期685-690,共6页中国药理学报（英文版）

基　　金：Project supported by the National Natural Science Foundation of China (№ 30271498);the National Basic Research Program of China (№ G1999054000).

摘　　要：Aim: To determine the distribution of cysteinyl leukotriene receptor 2 (CysLT_2), one of the cysteinyl leukotriene receptors, in human brains with traumatic injury and tumors. Methods: Brain specimens were obtained from patients who underwent brain surgery. CysLT_2 in brain tissues was examined using immunohis-tochemical analysis. Results: CysLT_2 was expressed in the smooth muscle cells (not in the endothelial cells) of arteries and veins. CysLT_2 was also expressed in the granulocytes in both vessels and in the brain parenchyma. In addition, CysLT_2 was detected in neuron- and glial-appearing cells in either the late stages of traumatic injury or in the area surrounding the tumors. Microvessels regenerated 8 d after trauma and CysLT_2 expression was recorded in their endothelial cells. Conclusion: CysLT_2 is distributed in vascular smooth muscle cells and granulocytes, and brain trauma and tumor can induce its expression in vascular endothelial cells and in a number of other cells.Aim: To determine the distribution of cysteinyl leukotriene receptor 2 (CysLT_2), one of the cysteinyl leukotriene receptors, in human brains with traumatic injury and tumors. Methods: Brain specimens were obtained from patients who underwent brain surgery. CysLT_2 in brain tissues was examined using immunohis-tochemical analysis. Results: CysLT_2 was expressed in the smooth muscle cells (not in the endothelial cells) of arteries and veins. CysLT_2 was also expressed in the granulocytes in both vessels and in the brain parenchyma. In addition, CysLT_2 was detected in neuron- and glial-appearing cells in either the late stages of traumatic injury or in the area surrounding the tumors. Microvessels regenerated 8 d after trauma and CysLT_2 expression was recorded in their endothelial cells. Conclusion: CysLT_2 is distributed in vascular smooth muscle cells and granulocytes, and brain trauma and tumor can induce its expression in vascular endothelial cells and in a number of other cells.

关 键 词：cysteinyl leukotriene receptor 2 brain injuries brain neoplasms vascular smooth muscle cell 

分 类 号：R651.15[医药卫生—外科学] R739.4[医药卫生—临床医学]